- Our goal is to to design and implement molecular containers, which can be dynamically opened and closed by an external stimulus.
- The containers will be implemented as DNA nanostructures, which afford a significant degree of positional control and chemical versatility.
- As an initial proof-of-concept, we plan to use our DNA containers to demonstrate controllable activation ("delivery") of anti-thrombin aptamers.
- We expect that molecular containers could have several interesting scientific and clinical applications, such as
- Drug and gene delivery
- Bio-marker scavenging (early detection of biomarkers)
- Directed evolution (compartmentalized selections)
- Using multiplexing for combinatorial chemical synthesis
- Capture and stabilization of multiprotein complexes
- Protein folding (chaperones)
- Cell sorting
Working Team Members
- Tiffany Chan (talk, edits)
- Katherine Fifer (talk, edits)
- Valerie Lau (talk, edits)
- Matthew Meisel (talk, edits)
20 November 2017
User:Sanuja Mohanaraj/Notebook/Experimental Biochemistry 1 Fall 2017/2017/09/12 (8 changes | history) . . (+509) . . [Sanuja Mohanaraj (8×)]
User:Casey M Culhane/Notebook/EBC Fall 2017/2017/09/13 (6 changes | history) . . (+961) . . [Casey M Culhane (6×)]
|20:44||(Upload log) . . Casey M Culhane uploaded File:EBC 9-13-17.pdf |
|19:39||BME100 f2017:Group9 W1030 L6 (diff | hist) . . (+656) . . Nicholas Y. Lee (→Intro to Computer-Aided Design)|