Difference between revisions of "IGEM:Harvard/2006/DNA nanostructures"

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<li id="current">[[IGEM:Harvard/2006/DNA nanostructures|Project Overview]]</li>
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<li>[[IGEM:Harvard/2006/DNA_nanostructures/Designs|Designs]]</li>
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<li>[[IGEM:Harvard/2006/DNA_nanostructures/Notebook|Notebook]]</li>
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<li>[[IGEM:Harvard/2006/DNA_nanostructures/Protocols|Protocols]]</li>
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<li>[[IGEM:Harvard/2006/DNA_nanostructures/Presentations|Presentations]]</li>
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<li>[[IGEM:Harvard/2006/DNA_nanostructures/Literature|Literature]]</li>
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==Project Overview==
 
==Project Overview==
*Our goal is to to design and implement molecular containers, which can be dynamically opened and closed by an external stimulus.
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*Our goal is to design and implement molecular containers, which can be dynamically opened and closed by an external stimulus.
 
*The containers will be implemented as DNA nanostructures, which afford a significant degree of positional control and chemical versatility.
 
*The containers will be implemented as DNA nanostructures, which afford a significant degree of positional control and chemical versatility.
 
*As an initial proof-of-concept, we plan to use our DNA containers to demonstrate controllable activation ("delivery") of anti-thrombin aptamers.
 
*As an initial proof-of-concept, we plan to use our DNA containers to demonstrate controllable activation ("delivery") of anti-thrombin aptamers.
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**Cell sorting
 
**Cell sorting
  
==Container Specs==
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==Working Team Members==
[[Image:Igemharv06_mattspecs.jpg]]
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*[[User:TChan|Tiffany Chan]] ([[User_talk:TChan|talk]], [[Special:Contributions/TChan|edits]])
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*[[User:Kfifer|Katherine Fifer]] ([[User_talk:Kfifer|talk]], [[Special:Contributions/Kfifer|edits]])
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*[[User:Vlau|Valerie Lau]] ([[User_talk:Vlau|talk]], [[Special:Contributions/Vlau|edits]])
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*[[User:Matthewmeisel|Matthew Meisel]] ([[User_talk:Matthewmeisel|talk]], [[Special:Contributions/Matthewmeisel|edits]])
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*[[User:Lhahn|Lewis Hahn]] ([[User_talk:Lhahn|talk]], [[Special:Contributions/Lhahn|edits]])
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*TA: [[User:ShawnDouglas|Shawn Douglas]] ([[User_talk:ShawnDouglas|talk]], [[Special:Contributions/ShawnDouglas|edits]])
  
==Container Designs==
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==Recent Changes==
<gallery>
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{{Special:Recentchanges/b=IGEM:Harvard/2006/DNA_nanostructures/&limit=20}}
Image:Igemharv06_Katie_Val_cylinderI.gif|[[IGEM:Harvard/2006/Container Design 1|Design 1]]<br>hexagonal core, separate 1-ply lids
 
Image:Smallcontainerdesign2.jpg|[[IGEM:Harvard/2006/Container Design 2|Design 2]]<br>hexagonal core, separate 2-ply lids
 
Image:Igemharv06_msmrect.png|[[IGEM:Harvard/2006/Container Design 3|Design 3]]<br>rectangular core, continuous 1-ply lids
 
Image:Websmallbarrsingleply.jpg|[[IGEM:Harvard/2006/Container Design 4|Design 4]]<br>hexagonal core, separate 1-ply lids
 
</gallery>
 
 
 
==Coding==
 
===Existing code===
 
*[[IGEM:Harvard/2006/DNA_nanostructures/Designing_DNA_nanostructures|William's code (Python)]]
 
 
 
==Presentations==
 
 
 
===Most recent (Week 3)===
 
* [[Media:IGEMHarv06 Week3 presentation VKTM2.ppt|Week 3 Presentation: Design Progress]]
 
 
 
===Week 2: Original proposal===
 
* [[IGEM:Harvard/2006/DNA_nanostructures/Presentation_proposal|Presentation Proposal]]
 
 
 
==Working Team Members==
 
*[[User:TChan|Tiffany Chan]] ([[User_talk:TChan|talk]])
 
*[[User:Kfifer|Katherine Fifer]] ([[User_talk:Kfifer|talk]])
 
*[[User:Vlau|Valerie Lau]] ([[User_talk:Vlau|talk]])
 
*[[User:Matthewmeisel|Matthew Meisel]] ([[User_talk:Matthewmeisel|talk]])
 

Latest revision as of 17:15, 28 October 2006



Project Overview

  • Our goal is to design and implement molecular containers, which can be dynamically opened and closed by an external stimulus.
  • The containers will be implemented as DNA nanostructures, which afford a significant degree of positional control and chemical versatility.
  • As an initial proof-of-concept, we plan to use our DNA containers to demonstrate controllable activation ("delivery") of anti-thrombin aptamers.
  • We expect that molecular containers could have several interesting scientific and clinical applications, such as
    • Drug and gene delivery
    • Bio-marker scavenging (early detection of biomarkers)
    • Directed evolution (compartmentalized selections)
    • Using multiplexing for combinatorial chemical synthesis
    • Capture and stabilization of multiprotein complexes
    • Protein folding (chaperones)
    • Cell sorting

Working Team Members

Recent Changes

23 February 2018

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22 February 2018

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