Difference between revisions of "IGEM:Harvard/2006/DNA nanostructures"

From OpenWetWare
Jump to: navigation, search
(Container Specs)
Line 13: Line 13:
==Container Specs==
==Container Specs==
==Container Designs==
==Container Designs==

Revision as of 06:30, 5 July 2006

Project Overview

  • Our goal is to to design and implement molecular containers, which can be dynamically opened and closed by an external stimulus.
  • The containers will be implemented as DNA nanostructures, which afford a significant degree of positional control and chemical versatility.
  • As an initial proof-of-concept, we plan to use our DNA containers to demonstrate controllable activation ("delivery") of anti-thrombin aptamers.
  • We expect that molecular containers could have several interesting scientific and clinical applications, such as
    • Drug and gene delivery
    • Bio-marker scavenging (early detection of biomarkers)
    • Directed evolution (compartmentalized selections)
    • Using multiplexing for combinatorial chemical synthesis
    • Capture and stabilization of multiprotein complexes
    • Protein folding (chaperones)
    • Cell sorting

Container Specs

File:Igemharv06 mattspecs.jpg

Container Designs


Existing code


Most recent (Week 3)

Week 2: Original proposal

Working Team Members