IGEM:Harvard/2006/Brainstorming with William

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What are the synonyms for containers?

Use these terms for web searches investigating potential applications of molecular containers

  • Capsules
  • Containers
  • Encapsulation
  • Vaults
  • Viruses
  • Vehicles
  • Vesicles
  • Liposomes
  • Vessels
  • Boxes
  • Compartments

What are the enabling features? (Can be optional features)

These are general capabilities for which there may or may not exist demand outside the field

  • Rigid or defined structure
  • Getting things in and out
  • Non-porous → doesn't leak in or out
  • Allows one to maintain different microenvironments (inside versus outside)
  • Allows multiplexed microenvironments
  • Selective permeability
  • Ability to fuse or separate
  • Caging and release
  • Controlled release
  • Specific targeting of container to destination
  • Robotics

What are potential applications for containers?

These are applications for which one suspects there may be demand in the outside community

  • Drug and gene delivery
    • Issues
      • Slow down the clearance time in plasma and intracellularly
      • Size of pores
      • Getting into cell
  • Directed evolution (compartmentalized selections)
  • Chemical synthesis
    • Increase effective concentration of reactants
    • Using multiplexing for combinatorial synthesis
  • Protein folding (chaperone)
  • Capture and stabilization of multiprotein complexes
  • Marker scavenging
  • Cell sorting (gattaca technology)

What are demand-meeting applications for containers?

Can move items from the "potential applications" list down to this list when you can find specific examples (i.e. names of molecules involved) where a demand exists for this application; for many people, this is the only list that matters

How exactly to implement container and lid?

Biotin/streptavinin docking?

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