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Our laboratory studies circadian rhythms as a model to better understand how the nervous system regulates behavior and physiology. We are especially interested in uncovering the mechanisms driving gene expression rhythms and determining how these molecular oscillations ultimately influence physiological rhythms. We use a combination of approaches, including behavioral neuroscience, molecular biology, genetics, genomics, and bioinformatics.


We also study the functional genomics of muscle using RNA-sequencing. Our recent work shows that thousands of transcripts are differentially expressed among skeletal muscle tissues. Current work in the lab aims to define the transcriptional pathways that establish muscle tissue identity, as well as exploring the role of microRNAs in skeletal muscle specialization.

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Hughes Lab
Pulmonary and Critical Care Medicine
Washington University School of Medicine