Difference between revisions of "Hoatlin Lab"

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'''Lab News'''
 
'''Lab News'''
*Now Inviting Applications for a [[Hoatlin:Postdoc|Postdoctoral Position]]
 
 
;For news, follow the [http://twitter.com/HoatlinLab Hoatlin lab Twitter]
 
;For news, follow the [http://twitter.com/HoatlinLab Hoatlin lab Twitter]
 
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Revision as of 16:09, 21 April 2010

Equipped with his five senses, man explores the universe around him and calls the adventure Science.  ~Edwin Powell Hubble, The Nature of Science, 1954

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Lab News

For news, follow the Hoatlin lab Twitter


Our laboratory is interested in understanding the molecular function of the Fanconi anemia (FA) protein network in context with other proteins that regulate or influence genomic stability. Fanconi anemia is a rare genetic disease that is typically associated with developmental abnormalities, bone marrow failure and increased risk of cancer. Because the majority of the FA proteins are unique with no significant homologies, we expect the results of our studies to shed new light on fundamental mechanisms that control the integrity of the human genome and influence cancer susceptibility. The FA pathway is part of a network of proteins that contains BRCA2 and two other recently identified FA genes (FANCN and FANCJ) that influence breast cancer susceptibility. Ultimately, insights into the mechanism of the FA/BRCA network of proteins will lead to an understanding of the underlying molecular defect in FA and may lead to more effective avenues of treatment for this devastating pediatric disease and cancer.

We work in Portland, Oregon at OHSU, in the Department of Biochemistry & Molecular Biology and the OHSU Knight Cancer Institute.

Quick Links

Genetic Mechanisms Class (CON662)

OHSU DNA Replication, Recombination and Repair (R3) Club.

BMB Seminar Series for 2009-2010

Advanced Topics in Molecular Biology(BMB625)

Who is Visiting Us?

Who's visiting?

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