Difference between revisions of "Hoatlin Lab"

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My laboratory in interested in understanding the molecular function of the Fanconi anemia (FA) protein network in context with other proteins that regulate or influence genomic stability. Fanconi anemia is a rare genetic disease that is typically associated with developmental abnormalities, bone marrow failure and increased risk of cancer. Because the majority of the FA proteins are unique with no significant homologies, we expect the results of our studies to shed new light on fundamental mechanisms that control the integrity of the human genome and influence cancer susceptibility.  The FA pathway is part of a network of proteins that contains BRCA2 and two other recently identified FA genes (FANCN and FANCJ) that influence breast cancer susceptibility.  Ultimately, insights into the mechanism of the FA/BRCA network of proteins will lead to an understanding of the underlying molecular defect in FA and may lead to more effective avenues of treatment for this devastating pediatric disease and cancer.  
 
My laboratory in interested in understanding the molecular function of the Fanconi anemia (FA) protein network in context with other proteins that regulate or influence genomic stability. Fanconi anemia is a rare genetic disease that is typically associated with developmental abnormalities, bone marrow failure and increased risk of cancer. Because the majority of the FA proteins are unique with no significant homologies, we expect the results of our studies to shed new light on fundamental mechanisms that control the integrity of the human genome and influence cancer susceptibility.  The FA pathway is part of a network of proteins that contains BRCA2 and two other recently identified FA genes (FANCN and FANCJ) that influence breast cancer susceptibility.  Ultimately, insights into the mechanism of the FA/BRCA network of proteins will lead to an understanding of the underlying molecular defect in FA and may lead to more effective avenues of treatment for this devastating pediatric disease and cancer.  
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We work in [[Hoatlin:Portland Oregon| Portland, Oregon]] at [http://www.ohsu.edu/ OHSU], in the [http://www.ohsu.edu/biochem/ Department of Biochemistry & Molecular Biology] and the [http://www.ohsucancer.com/ OHSU Knight Cancer Institute].
  
 
;For news, follow the [http://twitter.com/HoatlinLab Hoatlin lab Twitter]
 
;For news, follow the [http://twitter.com/HoatlinLab Hoatlin lab Twitter]

Revision as of 14:35, 3 December 2008

Equipped with his five senses, man explores the universe around him and calls the adventure Science.  ~Edwin Powell Hubble, The Nature of Science, 1954

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My laboratory in interested in understanding the molecular function of the Fanconi anemia (FA) protein network in context with other proteins that regulate or influence genomic stability. Fanconi anemia is a rare genetic disease that is typically associated with developmental abnormalities, bone marrow failure and increased risk of cancer. Because the majority of the FA proteins are unique with no significant homologies, we expect the results of our studies to shed new light on fundamental mechanisms that control the integrity of the human genome and influence cancer susceptibility. The FA pathway is part of a network of proteins that contains BRCA2 and two other recently identified FA genes (FANCN and FANCJ) that influence breast cancer susceptibility. Ultimately, insights into the mechanism of the FA/BRCA network of proteins will lead to an understanding of the underlying molecular defect in FA and may lead to more effective avenues of treatment for this devastating pediatric disease and cancer.

We work in Portland, Oregon at OHSU, in the Department of Biochemistry & Molecular Biology and the OHSU Knight Cancer Institute.

For news, follow the Hoatlin lab Twitter

Quick Links

OHSU DNA Replication, Recombination and Repair (R3) Club.

BMB Seminar Series for 2008-2009

Advanced Topics in Molecular Biology(BMB625)

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Recent changes

17 December 2017

     15:18  BioBarakken:Back Door‎ (diff | hist) . . (+12). . Truong-Giang Anh Nguyen (talk | contribs) (Articles of association)

16 December 2017

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Kartzinel:Computing Resources‎‎ (5 changes | history) . . (+1,696). . [Tyler R. Kartzinel‎ (5×)]

     

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(cur | prev) . . (+174). . Tyler R. Kartzinel (talk | contribs) (Created page with "The http://www.kartzinellab.com Kartzinel Lab of Conservation Biology & Molecular Ecology *Tyler R. Kartzinel *Brown University *85 Waterman Street *Providence, RI 02906")

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User:JernejTurnsek‎‎ (12 changes | history) . . (+328). . [Jernej Turnsek‎ (12×)]

     

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15 December 2017

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10K Genes‎‎ (6 changes | history) . . (+113). . [Koeng‎ (6×)]

     

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     13:15 (Move log) . . Koeng (talk | contribs) moved page 10K Genes/JSON database to 10K Genes/JSON data file

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