Difference between revisions of "Hoatlin Lab"

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{{HoatlinLab}}
 
{{HoatlinLab}}
  
Our lab is interested in understanding how the [http://www.fanconi.org/ Fanconi anemia] proteins contribute to genomic stability with the goal of developing drugs that will help Fanconi patients and those who are susceptible to developing cancer.
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My laboratory in interested in understanding the molecular function of the Fanconi anemia (FA) protein network in context with other proteins that regulate or influence genomic stability. Fanconi anemia is a rare genetic disease that is typically associated with developmental abnormalities, bone marrow failure and increased risk of cancer. Because the majority of the FA proteins are unique with no significant homologies, we expect the results of our studies to shed new light on fundamental mechanisms that control the integrity of the human genome and influence cancer susceptibility. The FA pathway is part of a network of proteins that contains BRCA2 and two other recently identified FA genes (FANCN and FANCJ) that influence breast cancer susceptibility. Ultimately, insights into the mechanism of the FA/BRCA network of proteins will lead to an understanding of the underlying molecular defect in FA and may lead to more effective avenues of treatment for this devastating pediatric disease and cancer.  
We work in [[Hoatlin:Portland Oregon| Portland, Oregon]] at [http://www.ohsu.edu/ OHSU], in the [http://www.ohsu.edu/biochem/ Department of Biochemistry & Molecular Biology].
 
 
 
We hope that other Fanconi labs will join us at [http://openwetware.org/wiki/ OpenWetWare] to speed FA research, stimulate collaborative efforts, facilitate reagent distribution, and expand communication. We also believe that an understanding of the complex and enigmatic Fanconi anemia protein network could benefit from the attention of systems/synthetic biologists already on OWW.
 
Please see [http://www.sciam.com/article.cfm?id=science-2-point-0-great-new-tool-or-great-risk link to Scientific American article] now online about OWW and Science 2.0.  
 
  
 
;For news, follow the [http://twitter.com/HoatlinLab Hoatlin lab Twitter]
 
;For news, follow the [http://twitter.com/HoatlinLab Hoatlin lab Twitter]

Revision as of 14:26, 3 December 2008

Equipped with his five senses, man explores the universe around him and calls the adventure Science.  ~Edwin Powell Hubble, The Nature of Science, 1954

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My laboratory in interested in understanding the molecular function of the Fanconi anemia (FA) protein network in context with other proteins that regulate or influence genomic stability. Fanconi anemia is a rare genetic disease that is typically associated with developmental abnormalities, bone marrow failure and increased risk of cancer. Because the majority of the FA proteins are unique with no significant homologies, we expect the results of our studies to shed new light on fundamental mechanisms that control the integrity of the human genome and influence cancer susceptibility. The FA pathway is part of a network of proteins that contains BRCA2 and two other recently identified FA genes (FANCN and FANCJ) that influence breast cancer susceptibility. Ultimately, insights into the mechanism of the FA/BRCA network of proteins will lead to an understanding of the underlying molecular defect in FA and may lead to more effective avenues of treatment for this devastating pediatric disease and cancer.

For news, follow the Hoatlin lab Twitter

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