Hoatlin:OHSU Genetic Mechanisms Class

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Equipped with his five senses, man explores the universe around him and calls the adventure Science.  ~Edwin Powell Hubble, The Nature of Science, 1954

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Links for Maureen Hoatlin's CON 662 Class Oct 2010

Bonus Materials

  1. Langston LD, Indiani C, and O'Donnell M. Whither the replisome: emerging perspectives on the dynamic nature of the DNA replication machinery. Cell Cycle. 2009 Sep 1;8(17):2686-91. DOI:10.4161/cc.8.17.9390 | PubMed ID:19652539 | HubMed [Replisome]
  2. Remus D and Diffley JF. Eukaryotic DNA replication control: lock and load, then fire. Curr Opin Cell Biol. 2009 Dec;21(6):771-7. DOI:10.1016/j.ceb.2009.08.002 | PubMed ID:19767190 | HubMed [Replication]
All Medline abstracts: PubMed | HubMed

Other Stuff

  • Upcoming seminars of interest that I mentioned in the lectures
    • Susan Forsburg. BMB Seminar Dec 14, 2010.
  1. Yao NY and O'Donnell M. Replisome structure and conformational dynamics underlie fork progression past obstacles. Curr Opin Cell Biol. 2009 Jun;21(3):336-43. DOI:10.1016/j.ceb.2009.02.008 | PubMed ID:19375905 | HubMed [Review]

Post Test

Links For Maureen Hoatlin's CON 662 Class Oct 2009

Bonus Materials

  1. Langston LD, Indiani C, and O'Donnell M. Whither the replisome: emerging perspectives on the dynamic nature of the DNA replication machinery. Cell Cycle. 2009 Sep 1;8(17):2686-91. DOI:10.4161/cc.8.17.9390 | PubMed ID:19652539 | HubMed [Replisome]
  2. Remus D and Diffley JF. Eukaryotic DNA replication control: lock and load, then fire. Curr Opin Cell Biol. 2009 Dec;21(6):771-7. DOI:10.1016/j.ceb.2009.08.002 | PubMed ID:19767190 | HubMed [Replication]
All Medline abstracts: PubMed | HubMed

Other Stuff

  • Upcoming seminars of interest that I mentioned in the lectures
    • Michael O'Donnell:The Dynamic Process of Copying Double-stand DNA, Thu, February 11, 2010, 12pm – 1pm st Portland State University, Science Building II, room 223
  1. Yao NY and O'Donnell M. Replisome structure and conformational dynamics underlie fork progression past obstacles. Curr Opin Cell Biol. 2009 Jun;21(3):336-43. DOI:10.1016/j.ceb.2009.02.008 | PubMed ID:19375905 | HubMed [Review]

Post Test

  • While you are waiting for your scores, enjoy some excellent animations. The virology animation includes viral replication. Viral styles of replication are complex and fascinating, also providing a target for therapeutic intervention.