Haynes Lab:Notebook/Synthetic Biology and Bioinformatics for Predictable Control of Therapeutic Gene2/2012/11/16: Difference between revisions
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==Genes of Focus== | ==Genes of Focus== | ||
There is a threshold of > 10^-3 | |||
<br/> | |||
'''HepG2''' | '''HepG2''' | ||
*TBD | *TBD | ||
'''K562''' | '''K562''' | ||
<br/> | <br/> | ||
All of these genes are listed under MAP Kinase Activity | ''All of these genes are listed under MAP Kinase Activity'' | ||
<br/> | <br/> | ||
1. MAPK14 | 1. MAPK14 | ||
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3. MAPK10 | 3. MAPK10 | ||
*Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis | *Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis | ||
Under phosphotransferase activity, alcohol group as acceptor | ''Under phosphotransferase activity, alcohol group as acceptor'' | ||
* | 4. RET | ||
*This gene plays a crucial role in neural crest development, and it can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. | |||
*Mutations in this gene are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma. | |||
5. FGFR4 | |||
*This particular family member preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis. | |||
6. CDK1A | |||
*The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. | |||
*The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. | |||
*Plays a regulatory role in S phase DNA replication and DNA damage repair. | |||
*May be instrumental in the execution of apoptosis following caspase activation. | |||
'''SK-N-SH RA''' | '''SK-N-SH RA''' | ||
''All under signaling receptor activity'' | |||
1. KIT | |||
*This gene encodes the human homolog of the proto-oncogene c-kit. C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. | |||
*Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism. | |||
2. TNFRSF11A | |||
*TNF-receptor superfamily (tumor necrosis factor) | |||
3. EGFR | |||
*Mutations in this gene are associated with lung cancer. | |||
''Sequence-Specific DNA Binding'' | |||
4. WT1 | |||
*It is mutated in a small subset of patients with Wilm's tumors | |||
5. HLF | |||
*Chromosomal translocations fusing portions of this gene with the E2A gene cause a subset of childhood B-lineage acute lymphoid leukemias. | |||
6. BCL6 | |||
*This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. | |||
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Revision as of 11:40, 19 November 2012
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Genes of FocusThere is a threshold of > 10^-3
K562
2. MAPK9
3. MAPK10
Under phosphotransferase activity, alcohol group as acceptor 4. RET
5. FGFR4
6. CDK1A
SK-N-SH RA All under signaling receptor activity 1. KIT
2. TNFRSF11A
3. EGFR
Sequence-Specific DNA Binding 4. WT1
5. HLF
6. BCL6
|