Difference between revisions of "Harmer Lab"

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*[[User:Jennifer_Gray|Jennifer Gray]]
*[[User:Jennifer_Gray|Jennifer Gray]]
*[[User:Yingshan_Hsu|Yingshan Hsu]]
*[[User:Yingshan_Hsu|Yingshan Hsu]]
*[[User:Ivan Salles Santos|Ivan Salles Santos]]
<h3><font style="color:#CA1F7B;">Former Members</font></h3>
<h3><font style="color:#CA1F7B;">Former Members</font></h3>

Revision as of 16:16, 10 December 2012

Lab image small.png

Room 2123
Department of Plant Biology
1002 Life Sciences, One Shields Ave.
University of California Davis
Davis, CA 95616

Contact: slharmer at ucdavis.edu

Home      Research      Publications      Protocols      Announcements      Lab Safety      Job openings     


Many organisms, including some prokaryotes and most eukaryotes, possess an internal timer or circadian clock that allows them to regulate their physiology to better adapt to our continually changing world. These circadian clocks generate roughly 24 hour rhythms in physiology and behavior that are maintained even in the absence of environmental cues. Although the molecular components of circadian clocks are not conserved across higher taxa, in all organisms studied these clocks are cell autonomous oscillators and in diverse eukaryotes are composed of complex transcriptional networks.

The study of circadian rhythms presents a wide range of interesting questions: What is the molecular nature of the circadian clock; that is, how can a cell keep time? What aspects of physiology are under circadian regulation? What are the mechanistic links between the clock network and other signaling pathways? Why does a functional circadian clock provide an adaptive advantage?

The Harmer lab is using Arabidopsis thaliana and sunflower to address these fundamental questions. We use forward and reverse genetics, genomics, biochemistry, and physiological studies to better understand the nature of the plant clock and how it helps shape plant responses to the environment.


Lab Members

Former Members

Selected Publications

  • Rawat, R., Takahashi, N., Hsu, P.Y., Jones, M.A., Schwartz, J., Salemi, M.R., Phinney, B.S., and Harmer, S.L. (2011) REVEILLE8 and PSEUDO-REPONSE REGULATOR5 form a negative feedback loop within the Arabidopsis circadian clock. PLoS Genetics, 7(3): e1001350. [1]
  • Jones, M.A., Covington, M.F., Ditacchio, L., Vollmers, C., Panda, S., Harmer, S.L. (2010) Jumonji domain protein JMJD5 functions in both the plant and human circadian systems. Proceedings of the National Academy of the Sciences 107(50): 21623-21628. [2]
  • Rawat, R., Schwartz, J., Jones, M.A., Sairanen, I., Cheng, Y., Andersson, C.R., Zhao, Y., Ljung, K., and Harmer, S.L. (2009). REVEILLE1, a Myb-like transcription factor, integrates the circadian clock and auxin pathways. Proceedings of the National Academy of the Sciences 106(39) 16883-16888. [3]
  • Harmer, S.L. (2009). The circadian system in higher plants. Annual Review of Plant Biology 60: 357 – 77. [4]
  • Covington, M.F., Maloof, J.N., Straume, M., Kay, S.A., and Harmer, S.L. (2008). Global transcriptome analysis reveals circadian regulation of key pathways in plant growth and development. Genome Biology, 9(8):R130. [5]
  • Covington, M.F. and Harmer, S.L (2007) The circadian clock regulates auxin signaling and responses in Arabidopsis. PLoS Biology, 5(8): e227 [6]
  • Nozue, K., Covington, M.F., Duek, P.D., Lorrain, S., Fankhauser, C., Harmer, S.L., and Maloof, J.N. (2007) Rhythmic growth explained by coincidence between internal and external cues. Nature, 448:358-61. [7]




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