Difference between revisions of "Frankel:HIV/Virus"

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''<font align="center" font color=#ffffff font size=8>_________ </font>'''''<font color=#000000 font size=8>HIV gp160</font>'''
'''<font align="center" font color=#ffffff font size=8>__________ </font>''''''<font color=#045FB4 font size=8>HIV gp160</font>'''
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[[Image:GP160_on_mica.png|235px]]
 
[[Image:GP160_on_mica.png|235px]]
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[[Image:Pore50nm.png|235px]]
 
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[[Image:Pore100nm.png|235px]]
 
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'''<font color=#045FB4 font size=3>HIV covers its protein capsid with a viral envelop where GP160 is located. This glycoprotein facilitates fusion between the viral membrane and the host -cell membrane allowing liberation of the viral contents into the host cell. GP160 forms a trimer, where each monomer consists in two non-covalently associated subunits: a surface subunit GP120 that recognize and bind to specific receptor on the host cell and a transmembrane subunit GP41 that promotes membrane fusion.</font>'''
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'''<font color=#000000 font size=3>HIV covers its protein capsid with a viral envelop where GP160 is located. This glycoprotein facilitates fusion between the viral membrane and the host -cell membrane allowing liberation of the viral contents into the host cell. GP160 forms a trimer, where each monomer consists in two non-covalently associated subunits: a surface subunit GP120 that recognize and bind to specific receptor on the host cell and a transmembrane subunit GP41 that promotes membrane fusion.</font>'''
  
 
[[Image:GIF-VIRUS-INFECTION1.gif|500px]]
 
[[Image:GIF-VIRUS-INFECTION1.gif|500px]]
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'''<font color=#045FB4 font size=3> Self assembly and pore formation of HIV gp160 revealed at molecular resolution
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Self assembly of HIV gp160 reconstituted into DOPC bilayer and adsorbed onto mica.
 
  
Images show gp160 forming pore like structures. Each pore is made up of 6 features with dimensions consistent with single molecules.
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'''<font color=#000000 font size=3>The images to the right show the self assembly of the HIV gp160 protein reconstituted into DOPC bilayer and adsorbed onto mica. Each pore is made up of 6 features with dimensions consistent with single molecules</font>'''

Latest revision as of 17:35, 9 January 2013

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_________ HIV gp160

GP160 on mica.png GP160 on DOPC.png Pore50nm.png Pore100nm.png GP160.png






HIV covers its protein capsid with a viral envelop where GP160 is located. This glycoprotein facilitates fusion between the viral membrane and the host -cell membrane allowing liberation of the viral contents into the host cell. GP160 forms a trimer, where each monomer consists in two non-covalently associated subunits: a surface subunit GP120 that recognize and bind to specific receptor on the host cell and a transmembrane subunit GP41 that promotes membrane fusion.

GIF-VIRUS-INFECTION1.gif




The images to the right show the self assembly of the HIV gp160 protein reconstituted into DOPC bilayer and adsorbed onto mica. Each pore is made up of 6 features with dimensions consistent with single molecules