Frankel:Force Spectroscopy

From OpenWetWare
Revision as of 09:19, 8 January 2013 by Daniel Frankel (talk | contribs)
Jump to: navigation, search

<owwmenu align="center" font="helvetica" bold="1" color="white" bgcolor="black" hovercolor="black" bghovercolor="orange" topfontsize="10" fontSize="10" image="Danbanner-bio-machines.jpg" >

Home=Frankel Members=#,Principal Investigator=Frankel:Lab_Members, PhD students=Frankel:Lab_Members, Alumni=Frankel:Lab_Members Contact=Frankel:Contact Collaborators=Frankel:Collaborators Publications=Frankel:Publications Lab=Frankel:Research Research=#,Force Spectroscopy=Frankel:Force Spectroscopy,HIV/Virus=Frankel:HIV/Virus,ECM Proteins=Frankel:ECM Proteins,Cyberplasm=Frankel:Cyberplasm,Cancer=Frankel:Cancer

'______ 'Force Spectroscopy


Nano-mechanics of HIV GP160

GP160mica.png GP 160.png




Typical sawtooth unfolding pattern of a single molecule of the HIV virion protein GP160. Unfolding forces can be extracted from the sawtooth pattern by applying the worm like chain model.

Unfolding the ECM protein fibronectin



Sawtooth pattern on the retraction force curve indicating the unfolding of fibronectin. The average rupture force distribution of the protein on mica surface was 85.1 ± 2.7 pN.