Frankel:Force Spectroscopy

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'______ 'Force Spectroscopy


Assembly

Nano-mechanics of HIV GP160


GP160mica.png

GP160mica

Stlow.png Hislow.png


Typical sawtooth unfolding pattern of a single molecule of the HIV virion protein GP160. Unfolding forces can be extracted from the sawtooth pattern by applying the worm like chain model.





Unfolding the ECM protein fibronectin


FNsawt.png


HisFN.png



Sawtooth pattern on the retraction force curve indicating the unfolding of fibronectin. The average rupture force distribution of the protein on mica surface was 85.1 ± 2.7 pN.