Frankel:Force Spectroscopy

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'______ 'Force Spectroscopy


Nano-mechanics of HIV GP160



Stlow.png Hislow.png

Typical sawtooth unfolding pattern of a single molecule of the HIV virion protein GP160. Unfolding forces can be extracted from the sawtooth pattern by applying the worm like chain model.

Unfolding the ECM protein fibronectin



Sawtooth pattern on the retraction force curve indicating the unfolding of fibronectin. The average rupture force distribution of the protein on mica surface was 85.1 ± 2.7 pN.