Difference between revisions of "Frankel:Force Spectroscopy"

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'''<font color=#FFFFFF font size=6>GP160mica</font>'''
 
'''<font color=#FFFFFF font size=6>GP160mica</font>'''
  
 
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'''<font color=#000000 font size=3> Unfolding the ECM protein fibronectin </font>'''
 
'''<font color=#000000 font size=3> Unfolding the ECM protein fibronectin </font>'''
 
  
 
[[Image:FNsawt.png|300px]]
 
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[[Image:HisFN.png|300px]]

Latest revision as of 17:22, 9 January 2013

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Home=Frankel Members=#,Principal Investigator=Frankel:Lab_Members, PhD students=Frankel:Lab_Members, Alumni=Frankel:Lab_Members Contact=Frankel:Contact Collaborators=Frankel:Collaborators Publications=Frankel:Publications Lab=Frankel:Research Research=#,Force Spectroscopy=Frankel:Force Spectroscopy,HIV/Virus=Frankel:HIV/Virus,ECM Proteins=Frankel:ECM Proteins,Cyberplasm=Frankel:Cyberplasm,Cancer=Frankel:Cancer


'______ 'Force Spectroscopy


Assembly

Nano-mechanics of HIV GP160


GP160mica.png


GP 160.png

GP160mica

Stlow.png

Hislow.png



Typical sawtooth unfolding pattern of a single molecule of the HIV virion protein GP160. Unfolding forces can be extracted from the sawtooth pattern by applying the worm like chain model.





Unfolding the ECM protein fibronectin

FNsawt.png

HisFN.png



Sawtooth pattern on the retraction force curve indicating the unfolding of fibronectin. The average rupture force distribution of the protein on mica surface was 85.1 ± 2.7 pN.