Difference between revisions of "Frankel:Cyberplasm"

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Revision as of 09:51, 2 March 2013

<owwmenu align="center" font="helvetica" bold="1" color="white" bgcolor="black" hovercolor="black" bghovercolor="orange" topfontsize="10" fontSize="10" image="Danbanner-bio-machines.jpg" >

Home=Frankel Members=#,Principal Investigator=Frankel:Lab_Members, PhD students=Frankel:Lab_Members, Alumni=Frankel:Lab_Members Contact=Frankel:Contact Collaborators=Frankel:Collaborators Publications=Frankel:Publications Lab=Frankel:Research Research=#,Force Spectroscopy=Frankel:Force Spectroscopy,HIV/Virus=Frankel:HIV/Virus,ECM Proteins=Frankel:ECM Proteins,Cyberplasm=Frankel:Cyberplasm,Cancer=Frankel:Cancer

_________ Cyberplasm - a biohybrid swimming robot

GP160 on mica.png GP160 on DOPC.png Pore50nm.png Pore100nm.png GP160.png

HIV covers its protein capsid with a viral envelop where GP160 is located. This glycoprotein facilitates fusion between the viral membrane and the host -cell membrane allowing liberation of the viral contents into the host cell. GP160 forms a trimer, where each monomer consists in two non-covalently associated subunits: a surface subunit GP120 that recognize and bind to specific receptor on the host cell and a transmembrane subunit GP41 that promotes membrane fusion.


The images to the right show the self assembly of the HIV gp160 protein reconstituted into DOPC bilayer and adsorbed onto mica. Each pore is made up of 6 features with dimensions consistent with single molecules