Difference between revisions of "Frankel:Cyberplasm"

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[[Image:GP160_on_mica.png|235px]]
 
[[Image:GP160_on_mica.png|235px]]

Revision as of 08:51, 2 March 2013

<owwmenu align="center" font="helvetica" bold="1" color="white" bgcolor="black" hovercolor="black" bghovercolor="orange" topfontsize="10" fontSize="10" image="Danbanner-bio-machines.jpg" >

Home=Frankel Members=#,Principal Investigator=Frankel:Lab_Members, PhD students=Frankel:Lab_Members, Alumni=Frankel:Lab_Members Contact=Frankel:Contact Collaborators=Frankel:Collaborators Publications=Frankel:Publications Lab=Frankel:Research Research=#,Force Spectroscopy=Frankel:Force Spectroscopy,HIV/Virus=Frankel:HIV/Virus,ECM Proteins=Frankel:ECM Proteins,Cyberplasm=Frankel:Cyberplasm,Cancer=Frankel:Cancer

_________ Cyberplasm - a biohybrid swimming robot

GP160 on mica.png GP160 on DOPC.png Pore50nm.png Pore100nm.png GP160.png






HIV covers its protein capsid with a viral envelop where GP160 is located. This glycoprotein facilitates fusion between the viral membrane and the host -cell membrane allowing liberation of the viral contents into the host cell. GP160 forms a trimer, where each monomer consists in two non-covalently associated subunits: a surface subunit GP120 that recognize and bind to specific receptor on the host cell and a transmembrane subunit GP41 that promotes membrane fusion.

GIF-VIRUS-INFECTION1.gif




The images to the right show the self assembly of the HIV gp160 protein reconstituted into DOPC bilayer and adsorbed onto mica. Each pore is made up of 6 features with dimensions consistent with single molecules