Drummond:Research

From OpenWetWare
Revision as of 16:36, 17 December 2011 by Dadrummond (talk | contribs) (new categories)
Jump to: navigation, search

Synthesis-to-misfolding.png

What are the spectrum, frequency and consequences of errors in protein synthesis? How do cells sense and respond to misfolded proteins, particularly in the eukaryotic cytosol? How does stochasticity in protein synthesis alter the composition and stability of the proteome? What benefits do errors confer? Does error-induced protein misfolding influence the progression of neurodegenerative diseases such as ALS?

We are pursuing mechanistic answers to these questions, taking a biochemical and genetic approach, with an emphasis on developing high-resolution, high-mass-accuracy mass spectrometric techniques for proteome-scale quantitation. From a theoretical standpoint, we are interested in understanding the imprints that natural selection on fidelity and misfolding leave on evolving genes and genomes.


Spectrum and frequency of errors in protein synthesis


Consequences of synthesis errors


Response to misfolded proteins


Under construction...thank you for your patience as we remodel to give you greater insight, improved clarity, and more images.