Drummond:Research

From OpenWetWare
Revision as of 13:51, 23 June 2007 by Dadrummond (talk | contribs) (top template)
Jump to: navigation, search

We've moved to http://drummondlab.org.

This site will not be updated.

the drummond lab

home      people      research      publications      news      protocols     


Key Questions

  1. What proportion of newly synthesized proteins fail to fold, and why?
  2. How do cells tell when a protein is misfolded, rather than simply in the process of folding? Do cells actually make such distinctions?
  3. What is the cost of producing a protein that misfolds, compared to the cost if that protein folds properly?
  4. Why are misfolded proteins costly?
  5. How does inaccuracy in the translational apparatus (ribosomes, aa-tRNA synthetases, etc.) shape the evolution of coding sequences and proteins?