Difference between revisions of "Curated HPA-Axis Models"

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(A mechanistic model of ACTH-stimulated cortisol secretion)
(A mechanistic model of ACTH-stimulated cortisol secretion)
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==A mechanistic model of ACTH-stimulated cortisol secretion==
 
==A mechanistic model of ACTH-stimulated cortisol secretion==
 +
Although this model is bit old, it can capture mechanistic behavior of the ACTH stimulated cortisol secretion.  GPCR signaling part is very much outdated and model does not consider the cholesterol uptake through LDL receptors pathway which is crucial for maximal steroid production
  
  
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<biblio>
 
<biblio>
 
#Dempsher_Gann_Phair_1984 pmid=6326602
 
#Dempsher_Gann_Phair_1984 pmid=6326602
 +
# pmid=16985254
 
</biblio>
 
</biblio>

Revision as of 13:53, 1 February 2010

A mechanistic model of ACTH-stimulated cortisol secretion

Although this model is bit old, it can capture mechanistic behavior of the ACTH stimulated cortisol secretion. GPCR signaling part is very much outdated and model does not consider the cholesterol uptake through LDL receptors pathway which is crucial for maximal steroid production



  1. Dempsher DP, Gann DS, and Phair RD. A mechanistic model of ACTH-stimulated cortisol secretion. Am J Physiol. 1984 Apr;246(4 Pt 2):R587-96. DOI:10.1152/ajpregu.1984.246.4.R587 | PubMed ID:6326602 | HubMed [Dempsher_Gann_Phair_1984]
  2. =16985254 [pmid]