Chien:Publications

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Publications

17. Vass, RH, Chien. P. "Critical clamp loader processing by an essential AAA+ protease in Caulobacter crescentus." Proc Natl Acad Sci U S A. 2013 Nov 5;110(45):18138-43. doi:10.1073/pnas.1311302110.

16. Jonas K, Liu J, Chien P, Laub MT. Proteotoxic Stress Induces a Cell-Cycle Arrest by Stimulating Lon to Degrade the Replication Initiator DnaA. Cell. 2013 Aug 1;154(3):623-36. PubMed PMID: 23911325.

15. Bhat NH, Vass RH, Stoddard PR, Shin DK, Chien P. Molecular Microbiology. Identification of ClpP substrates in Caulobacter crescentus reveals a role for regulated proteolysis in bacterial development. Mol Microbiol. 2013 May 7. doi: 10.1111/mmi.12241.

14. Gora KG*, Cantin A*, Wohlever M, Joshi KK, Perchuk BS,Chien P#, Laub MT#. Regulated proteolysis of a transcription factor complex is critical to cell cycle progression in Caulobacter crescentus. Molecular Microbiology 2013 Mar;87(6):1277-89. *equal contribution #corresponding authors.

13. Rood KL, Clark NE, Stoddard PR, Garman SC, Chien P. Adaptor-Dependent Degradation of a Cell-Cycle Regulator Uses a Unique Substrate Architecture. Structure. 2012 Jun 7. [Epub ahead of print] PubMed PMID: 22682744.

12. Landgraf D, Okumus B, Chien P, Baker TA, Paulsson J. Segregation of molecules at cell division reveals native protein localization. Nat Methods. 2012 Apr 8. doi: 10.1038/nmeth.1955. [Epub ahead of print] PubMed PMID: 22484850.

11. Abel S*, Chien P*, Wassmann P, Schirmer T, Kaever V, Laub MT, Baker TA, Jenal U. Regulatory Cohesion of Cell Cycle and Cell Differentiation through Interlinked Phosphorylation and Second Messenger Networks. Mol Cell. 2011 Aug 19;43(4):550-60. PubMed PMID: 21855795. *denotes equal contribution

10. Chowdhury T, Chien P, Ebrahim S, Sauer RT, Baker TA. Versatile modes of peptide recognition by the ClpX N domain mediate alternative adaptor-binding specificities in different bacterial species. Protein Sci. 2010 Feb;19(2):242-54. PubMed PMID: 20014030; PubMed Central PMCID: PMC2865724.

9. Kobayashi H, De Nisco NJ, Chien P, Simmons LA, Walker GC. Sinorhizobium meliloti CpdR1 is critical for co-ordinating cell cycle progression and the symbiotic chronic infection. Mol Microbiol. 2009 Aug;73(4):586-600. Epub 2009 Jul 7. PubMed PMID: 19602145; PubMed Central PMCID: PMC2756024.

8. Chien P, Grant RA, Sauer RT, Baker TA. Structure and substrate specificity of an SspB ortholog: design implications for AAA+ adaptors. Structure. 2007 Oct;15(10):1296-305. PubMed PMID: 17937918.

7. Chien P, Perchuk BS, Laub MT, Sauer RT, Baker TA. Direct and adaptor-mediated substrate recognition by an essential AAA+ protease. Proc Natl Acad Sci U S A. 2007 Apr 17;104(16):6590-5. Epub 2007 Apr 9. PubMed PMID: 17420450; PubMed Central PMCID: PMC1871830.

6. Tanaka M, Chien P, Yonekura K, Weissman JS. Mechanism of cross-species prion transmission: an infectious conformation compatible with two highly divergent yeast prion proteins. Cell. 2005 Apr 8;121(1):49-62. PubMed PMID: 15820678.

5. Chien P, Weissman JS, DePace AH. Emerging principles of conformation-based prion inheritance. Annu Rev Biochem. 2004;73:617-56. Review. PubMed PMID: 15189155.

4. Tanaka M, Chien P, Naber N, Cooke R, Weissman JS. Conformational variations in an infectious protein determine prion strain differences. Nature. 2004 Mar 18;428(6980):323-8. PubMed PMID: 15029196.

3. Chien P, DePace AH, Collins SR, Weissman JS. Generation of prion transmission barriers by mutational control of amyloid conformations. Nature. 2003 Aug 21;424(6951):948-51. PubMed PMID: 12931190.

2. Chien P, Weissman JS. Conformational diversity in a yeast prion dictates its seeding specificity. Nature. 2001 Mar 8;410(6825):223-7. PubMed PMID: 11242084.

1. Santoso A, Chien P, Osherovich LZ, Weissman JS. Molecular basis of a yeast prion species barrier. Cell. 2000 Jan 21;100(2):277-88. PubMed PMID: 10660050.
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