Chandra:Research:Computational immunology: Difference between revisions
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(New page: A key step in rational vaccine development is to understand how antigens are recognized by their receptors. Several crystal structures of MHC/HLA molecules are now available. We have perfo...) |
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A key step in rational vaccine development is to understand how antigens are recognized by their receptors. Several crystal structures of MHC/HLA molecules are now available. We have performed a structural bioinformatics study of peptide- HLA complexes to derive features that generate recognition specificity, useful for guiding the design process. | A key step in rational vaccine development is to understand how antigens are recognized by their receptors. Several crystal structures of MHC/HLA molecules are now available. We have performed a structural bioinformatics study of peptide- HLA complexes to derive features that generate recognition specificity, useful for guiding the design process. | ||
[[Image:Chandra | [[Image:Chandra-StructSuperposition.jpg|thumbnail|200px|left|Structural superposition of MHC Class I alleles]] | ||
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A key step in rational vaccine development is to understand how antigens are recognized by their receptors. Several crystal structures of MHC/HLA molecules are now available. We have performed a structural bioinformatics study of peptide- HLA complexes to derive features that generate recognition specificity, useful for guiding the design process.
