Difference between revisions of "CH391L/S13/Optogenetics"

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Revision as of 22:02, 24 February 2013

Introduction to Optogenetics

"Before we can find the answers, we need the power to ask new questions." -Karl Deisseroth

History

"The brain is a world consisting of a number of unexplored continents and great stretches of unknown territory." - Santiago Ramón y Cajal

Biochemistry behind Optogenetics

The Optogenetic Process

Gene Delivery

Controlled Illumination

Applications of Optogenetics

Neuroscience

Cardiology: Pacemakers

Hepatology: Diabetes and Beta Cells

IGEM Take-home Message

http://2012.igem.org/Team:Washington/Optogenetics http://2006.igem.org/wiki/index.php/University_of_Texas_2006 http://2006.igem.org/wiki/index.php/UT_Austin_2005 http://2004.igem.org/austin.cgi

References

  1. Mei Y and Zhang F. Molecular tools and approaches for optogenetics. Biol Psychiatry. 2012 Jun 15;71(12):1033-8. DOI:10.1016/j.biopsych.2012.02.019 | PubMed ID:22480664 | HubMed [Mei2012]
  2. Yizhar O, Fenno L, Zhang F, Hegemann P, and Diesseroth K. Microbial opsins: a family of single-component tools for optical control of neural activity. Cold Spring Harb Protoc. 2011 Mar 1;2011(3):top102. PubMed ID:21363959 | HubMed [Yizhar2011]
  3. Zemelman BV, Lee GA, Ng M, and Miesenböck G. Selective photostimulation of genetically chARGed neurons. Neuron. 2002 Jan 3;33(1):15-22. PubMed ID:11779476 | HubMed [Zemelman2002]
  4. LaLumiere RT. A new technique for controlling the brain: optogenetics and its potential for use in research and the clinic. Brain Stimul. 2011 Jan;4(1):1-6. DOI:10.1016/j.brs.2010.09.009 | PubMed ID:21255749 | HubMed [Lalumiere2011]
  5. Doroudchi MM, Greenberg KP, Liu J, Silka KA, Boyden ES, Lockridge JA, Arman AC, Janani R, Boye SE, Boye SL, Gordon GM, Matteo BC, Sampath AP, Hauswirth WW, and Horsager A. Virally delivered channelrhodopsin-2 safely and effectively restores visual function in multiple mouse models of blindness. Mol Ther. 2011 Jul;19(7):1220-9. DOI:10.1038/mt.2011.69 | PubMed ID:21505421 | HubMed [Doroudchi2011]
  6. Boyden ES, Zhang F, Bamberg E, Nagel G, and Deisseroth K. Millisecond-timescale, genetically targeted optical control of neural activity. Nat Neurosci. 2005 Sep;8(9):1263-8. DOI:10.1038/nn1525 | PubMed ID:16116447 | HubMed [Boyden2005]
All Medline abstracts: PubMed | HubMed