CH391L/S12/In vitro Selection
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Overview of in vitro selection
Library Generation
Randomized Oligodeoxynucleotides
Mutagenic PCR
Gene Shuffling
Neutral Drift
Confinement of Function
Binding
Cis-action
Cellularization
In vitro Compartmentalization
Increased Representation
Binding
Protection
Selective Amplification
FACS
History
Nucleic Acids
Aptamers
Ellington 1990
Ribozymes
Bartel 1993
Proteins
Antibodies
Accepting suggestions
DNA Modifying Proteins
Tawfik 1998
Other Enzymatic Functions
Self-Replication
Ghadessy 2001