Biomod/2013/Todai

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   <br>

<div class="sidebar">

 <ul>
    <li><a href="http://openwetware.org/wiki/Biomod/2013/Todai">Home</a>
    </li>
    <li><a href="http://openwetware.org/wiki/Biomod/2013/Todai/Project">Project</a>
    </li>
    <li><a href="http://openwetware.org/wiki/Biomod/2013/Todai/Design">Design</a>
    </li>
    <li><a href="http://openwetware.org/wiki/Biomod/2013/Todai/Result">Result</a>
    </li>
    <li><a href="http://openwetware.org/wiki/Biomod/2013/Todai/Experiment">Experiment</a>
       <ul style="list-style-type: none;">

<li>

          <a href="http://openwetware.org/wiki/Biomod/2013/Todai/Experiment#Contents">
          Contents</a></li>
          <li>
          <a href="http://openwetware.org/wiki/Biomod/2013/Todai/Experiment#PilotStudy">
          Pilot Study</a></li>
          <li>
          <a href="http://openwetware.org/wiki/Biomod/2013/Todai/Experiment#Protocols">
          Protocols</a></li>
       </ul>
    </li>
    <li><a href="http://openwetware.org/wiki/Biomod/2013/Todai/Team">Team</a>
    </li>
    <li><a href="http://openwetware.org/wiki/Biomod/2013/Todai/Sponsors">Sponsors</a>
    </li>
 </ul>

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<body>

  <h1 class="big-title"><a name="Home">&nbsp;Home</a></h1>
  <br>


  <article>
   <h1 class="title"><a name="Oligomeric Cell Killer">&nbsp;Oligomeric Cell 

Killer</a></h1>

    <p class="paragraph">Team Todai nanORFEVRE tried to make cancer-specific 

pore-forming DNA origami drug.</p>

   <p class="paragraph">We named this DNA nanostructure "Oligomeric Cell 

Killer".</p>

  </article>
  <br>
  <article>
     <h1 class="title"><a name="Abstract">&nbsp;Abstract</a></h1>
     <br>
  <center><iframe width="480" height="360" src="//www.youtube.com/embed/E4RaZ41hJ7w" frameborder="0" allowfullscreen></iframe>
  </center>

<br>

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  <img src="http://openwetware.org/images/4/46/Todai_home.png" width="450px" 

height="350px" >

  </center>
  </figure>
  <br>
  <p class="paragraph">

Cancer is one of the most common diseases in the world. Chemotherapy is a

popular treatment for cancer, however, it attacks normal cells in addition to

cancer cells, causing severe side effects in some cases. Recently drug

delivery system (DDS) has developed to improve cancer-specificity, but it is

difficult to optimize delivery system for each drug.

  </p>
   <br>
 <p class="paragraph">

Here, we tried to make a prototype of <span style="color:#e00000">oligomeric

cancer specific pore-forming DNA origami</span>, termed <span

style="color:#e00000"><b>Oligomeric Cell Killer (OCK)</b></span>, which might

be a side effects free anti-cancer drug.

  </p>
  <br>
 <p class="paragraph">

OCKs exist in a monomeric form in solution and penetrate into the cell

randomly. Cancer specific molecules on the membrane of cancer cell trigger

the oligomerization of OCK, resulting in the pore-forming and <span

style="color:#e00000">subsequent death of cancer cell</span>. In contrast,

the OCKs keep monomeric form in the normal cell, allowing <span

style="color:#e00000">the normal cell to keep alive</span>.

Our study might be the basis for cancer specific drug. 
  </p>
  <br>


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