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 <section role="main">



There is the system amplifying a tiny signal and transporting it in life.
Important and tiny reaction also exist in the natural world. Life don’t survive if they can’t correspond to these tiny signal. So existing life have evolved in the system amplifying a tiny change, transporting it and sensing. In fact, these signal transportation system is very important and there are various signal transporting system in general signal transport systems in sensitive organs, immune reaction and nerve message.
As I wrote above, it is very important to construct the system of releasing molecule in nanoscale size and there are many basic research to construct these system.

<img src="">
図1 生物の微小なシグナルに対する反応の例(ヒトは自然界の微小なシグナルを検知してそれを体内に伝達し、それに対処する反応ができる)


If we can imitate the signal transport system life use and construct molecular releasing system human can design, can we release molecular more effectively? The system can amplify tiny reaction to bigger one. We can awake phenomena we have never noticed. We can see the world we have never found. These discoveries enables to develop for humans; dawn of artificial evolution, not natural selection.
This system is expected to conduct DDS to inflammation human can’t sense automatically and transport signal which is faster than nerve.

<img src="">
図2 感知できなかったものが感知できるようになる世界(体内でヒトの無自覚に進行する血管の炎症を無自覚のうちに人工的な分子放出システムが治療する。これは新たな免疫系の獲得であり、「人工的な進化」である。)

Project Goal

To make tiny reaction we have never sensed sensitive size, we have to make the system sensing tiny signal and amplifying at an exponential rate. In that respect, the molecular releasing system life use can transport and amplify tiny reaction. We used this system as a reference and set out to construct the molecular releasing system that human can design.
<img src="">

図3 微小な反応を感知してそれを感知できる大きさに増幅する分子放出システムに必要な要素

To construct the molecular releasing system, following things are needed.
(1) Various molecular ejection (output) can be commanded from various stimulus (entry).
To accomplish this point, we have to make cases to confine various molecular and arrange mechanisms to open the case (mechanism to release)
(2) To operate release reaction in response to only a specific external stimulus As signals to release, there are various thing like light, pH, concentration of chemical agent, electro-charged field.
To operate release reaction, we have to make cases to react to only these changes.
(3)To build relationship to release molecular
If one tiny stimulus opens one case, it is no use occurring the reaction singly. Considering this factor, we have to make a mechanism to build relationships between the cases and molecular in the case and to amplify the reaction due to keeping behavior continue time after time. To resolve above problems, we have to design molecular that can opens the top of the case.
(4)To control the amount of molecular and when the cases will release the molecular. When the system senses stimulus, it have to control the amount of molecular and when the case will release the molecular. Even though these stimulus and releasing amount are tiny, this system have to release molecular except noises.
In other words, a certain level of the proportion of input and output (gain) is needed.
→confer simulation



As the case meeting above condition (1) and (2), we used liposome. There are two reasons to select. Liposome can confine various molecular and can be modified various molecular. ( correspond to (1)). Many liposome sensing one specific external stimulus are designed like temperature-sensitive one, light sensitive one and pH sensitive one. ( correspond to (2))

  • ref

To meet the (3) condition, we designed the system that DNA release molecular. We selected DNA because it has specificity and optionality by designing it.
However, anyone haven’t tried to collapse by DNA. This point is the most important and the hardest barrier.
Finally, to demonstrate validity, we ran a simulation
Establish a link here (by Off-san)

From above things, various system of releasing can be created. Among various system, this project aims at the releasing system releasing DNA from liposome when temperature rises and DNA collapse other ones containing DNA.
In this system, the collapse of liposome prevails chain-reactively and looks like Japanese HANABI (fireworks). So we call this system Lipo-HNANBI.





© Copyright Biomod 2013 Team Sendai <a href="">                   <img src="" width="180" height="50" alt="Molcular Robotics Lab" border="0" align="right">          </a>     

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