Difference between revisions of "Biomod/2013/Sendai/future"

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<h2>Future</h2>
 
<h2>Future</h2>
The advantage of our system is that large quantity of substances can be released at the desired timing and place. <br>私たちのプロジェクトを応用すれば以下のようなことが実現できる可能性がある<br>
+
Lipo-Hanabi is able to release a lot of molecules anytime and anywhere.
 +
Such versatility is essential in potential applications as follows.<br>
 +
 
 +
 
 +
<br><br>
  
<img src="http://openwetware.org/images/1/1d/Future1.2.png"><br><br>
+
<h3>Example 1 Sensing and curing inflammations in blood vessels</h3>
 +
Inflammation in blood vessels is a typical symptom difficult to diagnose. Therefore, they could get worse while you don’t even notice it.<br>
 +
The only way to detect blood vessel inflammation is to do a constant physical checkup. Lipo-Hanabi enables us to detect inflammations easily and gives us enough time to cure them. <br>
 +
Specific design will be as follows. C-reactive protein (CRP) is released in the inflammation. So we can use Liposomes conjugated with phosphorylcholine (one of phosphatides react with CRP) as the 1st stage detector for Lipo-Hanabi system. Then the 2nd stage liposomes release medicine at inflammation area effectively.<br>
  
<h3>Example 1 血管の炎症の感知と治療</h3>
+
Applications of Lipo-Hanabi are not limited to inflammations. As it can sense even very faint trigger signal and release large amount of drugs, it would help us to detect cancer cells in early stage while they are curable with small amount of anti-cancer agents.<br><br>
  
自分の血管で起こっている炎症の中には痛みを感じず、自分の知らない間に悪化してしまう。<br>
 
これらのシグナルを早期に発見するためには検査回数を増やすという方法しかなかった。
 
私たちのプロジェクトを応用すれば無自覚に進行している炎症を早期に発見して治療することができそうだ。<br>
 
血管の炎症からはC-反応性タンパク質(CRP)というシグナルが出ている。<br>
 
ファーストステージでは表面にホスホリルコリン(CRPと反応するリン脂質の一種)を含むリポソームが炎症部位を感知して割れる。内部の鍵DNAが放出される。<br>
 
セカンドステージでは鍵DNAがハイブリすることで割れる。内部に薬を入れておくことで狭い炎症部位に効果的に薬分子を放出できる。<br>
 
  
血管の炎症だけでなく無自覚に進行してしまうガンなどの治療やにも使えるだろう。would prevent the side effects by anti-cancer agent, and releasing large amount of drug by a small quantity of triggers offers the effective treatment for cancer.<br>
 
 
<br>
 
<br>
<img src="http://openwetware.org/images/c/cf/Future-fig-01.jpg"><br>
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<div align="center">
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<img src="http://openwetware.org/images/b/b9/%E3%83%97%E3%83%AD%E3%82%B8%E3%82%A7%E3%82%AF%E3%83%88%EF%BC%92lkjg.png" width="65%" height="65%"><br>
 +
Fig.1 Sensing and curing inflammations in blood vessels
 +
</div>
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 +
 
 +
 
  
<h3>Example 2 olecular engine</h3>
+
<h3>Example 2 molecular fuel supply</h3>
  
Moreover, focusing on the chain reaction, our system can be applied to long-lasting batteries for molecular engines.  
+
Focusing on the chain-reaction, Lipo-Hanabi can be applied to long-lasting batteries for molecular engines. If fuel for the molecular engines (such as ATP) is packed inside the liposome, they can constantly supply fuels to the molecular motor by a specific external signal. This kind of fuel supply system will be very useful to realize self-sustained molecular robots in the future.<br>
何で?
 
If some fuel for molecular engines (such as ATP) is packed inside the liposome, and the liposome is combined with some molecular motors (such as motor proteins), the fuel can be constantly supplied to the molecular motor by only one time initiation of the reaction. <br>
 
The molecular motor would lead to molecular engines, and in the end, sophisticated molecular robots. Our system would make it possible to achieve molecular robots moving without continuous fuel supply from the outside.<br><br>
 
  
<img src="http://openwetware.org/images/3/31/Future2.png"<br><br>
+
<div align="center">
Fig2.Molecular engine<br><br>
+
<img src="http://openwetware.org/images/6/6a/Molecular-engineklug.png" width="95%" ><br>
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Fig. 2 Molecular fuel supply system</div>
  
 
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<h2>Future</h2> Lipo-Hanabi is able to release a lot of molecules anytime and anywhere. Such versatility is essential in potential applications as follows.<br>


<br><br>

<h3>Example 1 Sensing and curing inflammations in blood vessels</h3> Inflammation in blood vessels is a typical symptom difficult to diagnose. Therefore, they could get worse while you don’t even notice it.<br> The only way to detect blood vessel inflammation is to do a constant physical checkup. Lipo-Hanabi enables us to detect inflammations easily and gives us enough time to cure them. <br> Specific design will be as follows. C-reactive protein (CRP) is released in the inflammation. So we can use Liposomes conjugated with phosphorylcholine (one of phosphatides react with CRP) as the 1st stage detector for Lipo-Hanabi system. Then the 2nd stage liposomes release medicine at inflammation area effectively.<br>

Applications of Lipo-Hanabi are not limited to inflammations. As it can sense even very faint trigger signal and release large amount of drugs, it would help us to detect cancer cells in early stage while they are curable with small amount of anti-cancer agents.<br><br>


<br> <div align="center"> <img src="http://openwetware.org/images/b/b9/%E3%83%97%E3%83%AD%E3%82%B8%E3%82%A7%E3%82%AF%E3%83%88%EF%BC%92lkjg.png" width="65%" height="65%"><br> Fig.1 Sensing and curing inflammations in blood vessels </div>



<h3>Example 2 molecular fuel supply</h3>

Focusing on the chain-reaction, Lipo-Hanabi can be applied to long-lasting batteries for molecular engines. If fuel for the molecular engines (such as ATP) is packed inside the liposome, they can constantly supply fuels to the molecular motor by a specific external signal. This kind of fuel supply system will be very useful to realize self-sustained molecular robots in the future.<br>

<div align="center"> <img src="http://openwetware.org/images/6/6a/Molecular-engineklug.png" width="95%" ><br> Fig. 2 Molecular fuel supply system</div>

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