Biomod/2012/Tohoku/Team Sendai: Difference between revisions

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<h1 style="margin-top:-50px;"><!--Team Sendai--><img src="http://openwetware.org/images/c/c2/Title-kai.png" ></h1>
    <title>Team Sendai Top</title>
<p>Tohoku University</p>
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{{:Biomod/2012/Tohoku/Team_Sendai/header}}
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<html>
<div id="Cntainer">
<!—二段組み本文 -->
<text-align="center"><h1>We want to create a new channel made of DNA!!(躍動感のあるフォントが欲しい)</h1>
<p>
We want to create a channel that does not exist in nature. DNA is a designable molecule and has interaction with various biomolecules. Thus, a channel made of DNA enables to transport more various biomolecules against energy gradient.
Such a new channel will be used…</br>
1. In medical care, because it can transport new molecules that are unable to be transported into cells without DNA.</br>
2. For sampling what we want from cells.</br>
3. For BIOROOMBA by compositing with artificial liposome.( Off course use for DDS)
（図が欲しい）</br>
</p>


</style>
</head>


<div id="pop">
<h2><!--Abstract-->Project Image</h2>
<img src="http://openwetware.org/images/4/46/Format_D-Heart.jpg" alt="D-Heart" width="400px"><br>
</div>


<div id="pop">
<h2>Movie</h2>
<!--
<p>Coming soon</p>
-->
<br><br>
<p style="text-align:center;">
<table style="border-style:solid;border-width:10px;width:400px;height:291px;background-color:black;border-color:#bbb;text-align:center;valign:middle;font-color:white;">
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<td style="color:white;">Coming soon...</td>
</tr>
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</div>
<h1 style="width:900px;clear:left;margin:15px;">
Abstract</h1>
<p style="width:900px;clear:left;margin:15px;">
&nbsp;All the creatures on Earth are made of cells. The exterior and the interior of the cell are compartmentalized by biomembranes.
A nanodevice that is able to actively transport only the specific oligonucleotide through the biomembrane has a great potential to deliver siRNA into the cell or to extract mRNA expressed in the cell.<br>
Here, we decided to create a novel device with such a function. <br>
We have designed a cylindrical injector/extractor device made of DNA origami. Inside the cylinder, a cascade of single stranded DNAs is planted. Once the outer-most ssDNA binds to a target oligonucleotide,　the target is passed to the inner-ones one by one because of the higher bonding energy assigned to the inner ones.<br>
We also investigate how the cylinder penetrates the biomembrane by using liposome as a model membrane.<br>
<br>
<strong>Selector</strong>: Single stranded DNA. Once the outer-most ssDNA binds to a target,　the target is passed to the inner-ones one by one.</br>
<strong>Gate</strong>: Cylindrical structure connecting the inside and outside like gates. A cascade of the "Selector" is planted in this. We can use this as an injector or extractor.</br>
<strong>Membrane</strong>: The exterior and the interior of the cell are compartmentalized by biomembranes. We use liposome as a model membrane.</br>
</p>


<a href=" http://openwetware.org/wiki/Biomod/2012/Team_Sendai_Old">Test page</a>
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<li><a href="http://openwetware.org/wiki/Biomod/2012/Tohoku/Team_Sendai ">Top</a></li>
<li><a href=" http://openwetware.org/wiki/Biomod/2012/TeamSendai/Idea ">Project</a></li>
<li><a href=" http://openwetware.org/wiki/Biomod/2012/TeamSendai/Design">Design</a>
</li>
<li><a href=" http://openwetware.org/wiki/Biomod/2012/TeamSendai/Simulation">Simulation</a>
</li>
<li>
<a href=" http://openwetware.org/wiki/Biomod/2012/TeamSendai/Experiment ">Experiment</a>
<ul>
<li>
<a href=" http://openwetware.org/wiki/Biomod/2012/TeamSendai/ Experiment#Gate">Gate</a> </li>
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<a href=" http://openwetware.org/wiki/Biomod/2012/TeamSendai/Experiment#Porter">Porter</a> </li>
<li> <a href=" http://openwetware.org/wiki/Biomod/2012/TeamSendai/ Experiment#Membrane">Membrane</a>
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<a href=" http://openwetware.org/wiki/Biomod/2012/TeamSendai/Achievement">Achievement</a>
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<a href=" http://openwetware.org/wiki/Biomod/2012/TeamSendai/Diary">Diary</a>
</li>
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<a href=" http://openwetware.org/wiki/Biomod/2012/TeamSendai/Team ">Team</a>
</li>
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<a href=" http://openwetware.org/wiki/Biomod/2012/Tohoku/Team Sendai/header"></a>
</li>


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Revision as of 06:08, 26 October 2012

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