Difference between revisions of "Biomod/2012/Tohoku/Team Sendai"

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#REDIRECT [[Biomod/2012/Team Sendai Old]]
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<h1 style="margin-top:-50px;"><!--Team Sendai--><img src="http://openwetware.org/images/c/c2/Title-kai.png" ></h1>
 +
<p>Tohoku University</p>
 +
</div>
 +
 
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<!-- Menu -->
 +
<ul id="menu">
 +
<li><a href="http://openwetware.org/wiki/Biomod/2012/TeamSendai/FinalTop#">Top</a></li>
 +
<li>
 +
<a href="#">Project</a>
 +
<ul>
 +
<li>
 +
<a href=" http://openwetware.org/wiki/Biomod/2012/TeamSendai/Idea">Idea</a>
 +
</li>
 +
<li>
 +
<a href=" http://openwetware.org/wiki/Biomod/2012/TeamSendai/Simulation">Simulation</a>
 +
</li>
 +
<li>
 +
<a href=" http://openwetware.org/wiki/Biomod/2012/TeamSendai/Design">Design</a>
 +
</li>
 +
</ul>
 +
</li>
 +
<li>
 +
<a href="#">Experiment</a>
 +
<ul>
 +
<li>
 +
<a href=" http://openwetware.org/wiki/Biomod/2012/TeamSendai/Result">Result</a>
 +
<ul>
 +
<li>
 +
<a href=" http://openwetware.org/wiki/Biomod/2012/TeamSendai/Result#Porter">Porter</a>
 +
<li>
 +
<a href=" http://openwetware.org/wiki/Biomod/2012/TeamSendai/Result#Cylinder">Cylinder</a> </li>
 +
<li> <a href=" http://openwetware.org/wiki/Biomod/2012/TeamSendai/Result# Vesicle">Vesicle</a>
 +
</li>
 +
</ul>
 +
<li><a href=" http://openwetware.org/wiki/Biomod/2012/TeamSendai/Method">Method</a> </li>
 +
</ul>
 +
</li>
 +
<li>
 +
<a href=" http://openwetware.org/wiki/Biomod/2012/TeamSendai/Diary">Diary</a>
 +
</li>
 +
<li>
 +
<a href=" http://openwetware.org/wiki/Biomod/2012/TeamSendai/Team ">Team</a>
 +
</li>
 +
</ul>
 +
 
 +
<!—二段組み本文 -->
 +
 
 +
<div id="pop">
 +
<h2><!--Abstract-->Project Image</h2>
 +
<img src="http://openwetware.org/images/4/46/Format_D-Heart.jpg" alt="D-Heart" width="400px"><br>
 +
</div>
 +
 
 +
<div id="pop">
 +
<h2>Movie</h2>
 +
<!--
 +
<p>Coming soon</p>
 +
-->
 +
<br><br>
 +
<p style="text-align:center;">
 +
<table style="border-style:solid;border-width:10px;width:400px;height:291px;background-color:black;border-color:#bbb;text-align:center;valign:middle;font-color:white;">
 +
<tr>
 +
<td style="color:white;">Coming soon...</td>
 +
</tr>
 +
</table>
 +
</p>
 +
</div>
 +
<h1 style="width:900px;clear:left;margin:15px;">
 +
Abstract</h1>
 +
<p style="width:900px;clear:left;margin:15px;">
 +
&nbsp;All the creatures on Earth are made of cells. The exterior and the interior of the cell are compartmentalized by biomembranes.
 +
A nanodevice that is able to actively transport only the specific oligonucleotide through the biomembrane has a great potential to deliver siRNA into the cell or to extract mRNA expressed in the cell.<br>
 +
Here, we decided to create a novel device with such a function. <br>
 +
We have designed a cylindrical injector/extractor device made of DNA origami. Inside the cylinder, a cascade of single stranded DNAs is planted. Once the outer-most ssDNA binds to a target oligonucleotide, the target is passed to the inner-ones one by one because of the higher bonding energy assigned to the inner ones.<br>
 +
We also investigate how the cylinder penetrates the biomembrane by using liposome as a model membrane.<br>
 +
<br>
 +
<strong>Selector</strong>: Single stranded DNA. Once the outer-most ssDNA binds to a target, the target is passed to the inner-ones one by one.</br>
 +
<strong>Gate</strong>: Cylindrical structure connecting the inside and outside like gates. A cascade of the "Selector" is planted in this. We can use this as an injector or extractor.</br>
 +
<strong>Membrane</strong>: The exterior and the interior of the cell are compartmentalized by biomembranes. We use liposome as a model membrane.</br>
 +
</p>
 +
 
 +
 
 +
<a href=" http://openwetware.org/wiki/Biomod/2012/Team_Sendai_Old">Test page</a>
 +
 
 +
</div>
 +
 
 +
</body>
 +
</html>

Revision as of 00:05, 20 October 2012

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<body> <div id="Container">

<!-- ヘッダー --> <div id="Header"> <h1 style="margin-top:-50px;"><!--Team Sendai--><img src="http://openwetware.org/images/c/c2/Title-kai.png" ></h1> <p>Tohoku University</p> </div>

<!-- Menu --> <ul id="menu"> <li><a href="http://openwetware.org/wiki/Biomod/2012/TeamSendai/FinalTop#">Top</a></li> <li> <a href="#">Project</a> <ul> <li> <a href=" http://openwetware.org/wiki/Biomod/2012/TeamSendai/Idea">Idea</a> </li> <li> <a href=" http://openwetware.org/wiki/Biomod/2012/TeamSendai/Simulation">Simulation</a> </li> <li> <a href=" http://openwetware.org/wiki/Biomod/2012/TeamSendai/Design">Design</a> </li> </ul> </li> <li> <a href="#">Experiment</a> <ul> <li> <a href=" http://openwetware.org/wiki/Biomod/2012/TeamSendai/Result">Result</a> <ul> <li> <a href=" http://openwetware.org/wiki/Biomod/2012/TeamSendai/Result#Porter">Porter</a> <li> <a href=" http://openwetware.org/wiki/Biomod/2012/TeamSendai/Result#Cylinder">Cylinder</a> </li> <li> <a href=" http://openwetware.org/wiki/Biomod/2012/TeamSendai/Result# Vesicle">Vesicle</a> </li> </ul> <li><a href=" http://openwetware.org/wiki/Biomod/2012/TeamSendai/Method">Method</a> </li> </ul> </li> <li> <a href=" http://openwetware.org/wiki/Biomod/2012/TeamSendai/Diary">Diary</a> </li> <li> <a href=" http://openwetware.org/wiki/Biomod/2012/TeamSendai/Team ">Team</a> </li> </ul>

<!—二段組み本文 -->

<div id="pop"> <h2><!--Abstract-->Project Image</h2> <img src="http://openwetware.org/images/4/46/Format_D-Heart.jpg" alt="D-Heart" width="400px"><br> </div>

<div id="pop"> <h2>Movie</h2> <!-- <p>Coming soon</p> --> <br><br> <p style="text-align:center;"> <table style="border-style:solid;border-width:10px;width:400px;height:291px;background-color:black;border-color:#bbb;text-align:center;valign:middle;font-color:white;"> <tr> <td style="color:white;">Coming soon...</td> </tr> </table> </p> </div> <h1 style="width:900px;clear:left;margin:15px;"> Abstract</h1> <p style="width:900px;clear:left;margin:15px;"> &nbsp;All the creatures on Earth are made of cells. The exterior and the interior of the cell are compartmentalized by biomembranes. A nanodevice that is able to actively transport only the specific oligonucleotide through the biomembrane has a great potential to deliver siRNA into the cell or to extract mRNA expressed in the cell.<br> Here, we decided to create a novel device with such a function. <br> We have designed a cylindrical injector/extractor device made of DNA origami. Inside the cylinder, a cascade of single stranded DNAs is planted. Once the outer-most ssDNA binds to a target oligonucleotide, the target is passed to the inner-ones one by one because of the higher bonding energy assigned to the inner ones.<br> We also investigate how the cylinder penetrates the biomembrane by using liposome as a model membrane.<br> <br> <strong>Selector</strong>: Single stranded DNA. Once the outer-most ssDNA binds to a target, the target is passed to the inner-ones one by one.</br> <strong>Gate</strong>: Cylindrical structure connecting the inside and outside like gates. A cascade of the "Selector" is planted in this. We can use this as an injector or extractor.</br> <strong>Membrane</strong>: The exterior and the interior of the cell are compartmentalized by biomembranes. We use liposome as a model membrane.</br> </p>


<a href=" http://openwetware.org/wiki/Biomod/2012/Team_Sendai_Old">Test page</a>

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