Billker:Rita Tewari

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I am a Research Lecturer associated with the Billker Lab

Major research interest on "Functional analysis of malaria parasite-host cell interactions in vivo using gene targeting". Presentally working on a genome-wide systematic deletion analysis of Plasmodium berghei protein kinases to reveal molecular mechanisms of life cycle regulation.

my email: r.tewari[AT]


  1. Tewari R, Dorin D, Moon R, Doerig C, and Billker O. An atypical mitogen-activated protein kinase controls cytokinesis and flagellar motility during male gamete formation in a malaria parasite. Mol Microbiol. 2005 Dec;58(5):1253-63. DOI:10.1111/j.1365-2958.2005.04793.x | PubMed ID:16313614 | HubMed [Tewari2005a]
  2. Reininger L, Billker O, Tewari R, Mukhopadhyay A, Fennell C, Dorin-Semblat D, Doerig C, Goldring D, Harmse L, Ranford-Cartwright L, Packer J, and Doerig C. A NIMA-related protein kinase is essential for completion of the sexual cycle of malaria parasites. J Biol Chem. 2005 Sep 9;280(36):31957-64. DOI:10.1074/jbc.M504523200 | PubMed ID:15970588 | HubMed [Reininger2005]
  3. Tewari R, Rathore D, and Crisanti A. Motility and infectivity of Plasmodium berghei sporozoites expressing avian Plasmodium gallinaceum circumsporozoite protein. Cell Microbiol. 2005 May;7(5):699-707. DOI:10.1111/j.1462-5822.2005.00503.x | PubMed ID:15839899 | HubMed [Tewari2005b]
  4. Tewari R, Ogun SA, Gunaratne RS, Crisanti A, and Holder AA. Disruption of Plasmodium berghei merozoite surface protein 7 gene modulates parasite growth in vivo. Blood. 2005 Jan 1;105(1):394-6. DOI:10.1182/blood-2004-06-2106 | PubMed ID:15339842 | HubMed [Tewari2005c]
  5. Billker O, Dechamps S, Tewari R, Wenig G, Franke-Fayard B, and Brinkmann V. Calcium and a calcium-dependent protein kinase regulate gamete formation and mosquito transmission in a malaria parasite. Cell. 2004 May 14;117(4):503-14. PubMed ID:15137943 | HubMed [Billker2004]
  6. Edvardsen RB, Lerat E, Maeland AD, Flåt M, Tewari R, Jensen MF, Lehrach H, Reinhardt R, Seo HC, and Chourrout D. Hypervariable and highly divergent intron-exon organizations in the chordate Oikopleura dioica. J Mol Evol. 2004 Oct;59(4):448-57. DOI:10.1007/s00239-004-2636-5 | PubMed ID:15638456 | HubMed [blabla]
  7. Gillemans N, McMorrow T, Tewari R, Wai AW, Burgtorf C, Drabek D, Ventress N, Langeveld A, Higgs D, Tan-Un K, Grosveld F, and Philipsen S. Functional and comparative analysis of globin loci in pufferfish and humans. Blood. 2003 Apr 1;101(7):2842-9. DOI:10.1182/blood-2002-09-2850 | PubMed ID:12517812 | HubMed [Gillemans2003]
All Medline abstracts: PubMed | HubMed

7. Gillemans N, McMorrow T, Tewari R, Wai AW, Burgtorf C, Drabek D, Ventress N, Langeveld A, Higgs D, Tan-Un K, Grosveld F, and Philipsen S (2003) A functional and comparative analysis of globin loci in pufferfish and man. Blood 101, 2842-2849.

8. Tewari R, Spaccapelo R, Bistoni F, Holder AA and Crisanti A (2002) Function of Region I and II adhesive motifs of Plasmodium falciparum circumsporozoite protein in sporozoite motility and infectivity. J. Biol. Chem. 49, 47613-47618.

9. Kropf P, Herath S, Tewari R, Syed N, Klemenz R, Müller I (2002) Identification of two distinct subpopulations of Leishmania major-specific T helper 2 cells. Infect. Immun. 70, 5512-5520.

10. Gillemans N, Tewari R, Lindeboom F, Rottier R, de Wit T, Wijgerde M, Grosveld F and Philipsen S (1998) Altered DNA -binding specificity mutants of EKLF and Sp1 show that EKLF is an activator of -globin locus control region in vivo. Gen. & Dev.15, 2863-2873.

11. Tewari R, Gillemans N, Wijgerde M , Von Lindern M , Grosveld F and Philipsen S (1998) Erythroid Kruppel - like factor (EKLF) is active in primitive and definitive erythroid cells and is required for the function of 5’HS3 of -globin locus control region. EMBO 17, 2334-2341.

12. Tewari R, Gillemans N, Harper A, Wijgerde M , Zafarana G, Drabek , Grosveld F, and Philipsen S. (1996) The human -globin locus control region confers an early embryonic erythroid -specific expression pattern to a basic promoter driving the bacterial lacZ gene. Development 122, 3991-3999.

13. Ellis J, Philipsen S, Strouboulis J, Pruzina S, Tewari R, Gillemans N, Drabek, D, Harper A, Grosveld F and Fraser P (1995). The regulation of human  globin gene expression; the roles of 5’HS1-4. Proceedings of the Ninth Conference on Hemoglobin Switching held at Orcas Island, 10-14 June 1994, editor Dr. G. Stamatoyannopoulos, pg. 29-38

14. Nakayama I, Foresti F, Tewari R, Schartl M and Chourrout D (1994) Sex chromosome polymorphism and heterogametic males revealed by two cloned DNA probes in ZW/ZZ fish Leporinus elongatus. Chromosoma 103, 31-39.

15. Tewari R , Michard-Vanhee C, Perrot E and Chourrout D (1992) Mendelian transmission, structure and expression of transgenes following their injection into the cytoplasm of trout eggs. Transgenic Research 1, 250-260.

16. Tewari R and Rao SRV (1991) Replication status of the fragile X chromosome and its implications for reproductive performance in the Indian mole rat (Nesokia indica). J.Reprod. Fert. 91, 203-206.

17. Thelma BK, Tewari R, Juyal RC and Rao SRV (1991). Random/non random X-inactivation in Nesokia indica: possible influence of heterochromatin. Cytogen. Cell Gen. 56, 87-90.

18. Tewari R, Juyal RC, Rao SRV and Thelma BK (1989). Significance of fragile sites on the sex chromosome of Nesokia indica. Nucleus 32, 93-102.

19. Thelma BK, Juyal RC, Tewari R and Rao SRV (1988). Does heterochromatin potentiate speciation? A study in Nesokia. Cytogen. Cell Gen. 47, 204-208.

20. Tewari R, Juyal RC, Thelma BK, Das BC and Rao SRV (1987). Folate sensitive fragile sites on the X-chromosome heterochromation of the Indian mole rat, Nesokia indica, Cytogen. Cell Gen. 44, 11-17.

21. Simon MM, Ali S, Tewari R, Simon HG, Muller-Hermelink HK and EpplenJT (1986) Leukemic cells arise from cloned cytotoxic lymphocytes during cell culture. Eur. J. Immun. 16, 1269-1276.