Billker:Rita Tewari

I am a Research Lecturer asociated to BillkerLab

Major reserach interest on "Functional analysis of malaria parasite-host cell interactions in vivo using gene targeting". Presentally working on a genome-wide systematic deletion analysis of Plasmodium berghei protein kinases to reveal molecular mechanisms of life cycle regulation.

my email: r.tewari[AT]imperial.ac.uk

Publication

1. Tewari R, Dorin D, Moon R, Doerig C and Billker O (2005) An atypical mitogen activated protein kinase controls cytokinesis and flagellar motility during male gamete formation in a malarial parasite. Mol. Microbiol. 58(5), 1253-1263

2. Reininger L, Billker O, Tewari R, A Mukhopadhyay A, Fennel C, Dorin-Semblat D, Doerig C, Goldring D, Ranford-Cartwright L, Packer J and C. Doerig (2005). A NIMA-related protein kinase is essential for completion of the sexual cycle of malaria parasites. J. Biol. Chem. 280(36), 31957-64.

3. Tewari R, Rathore D and Crisanti A (2005) Motility and infectivity of rodent malaria Plasmodium berghei sporozoites expressing avian Plasmodium gallinaceum circumsporozoite protein. Cell. Microbiol.7, 699-707.

4. Tewari R, Ogun S, Gunaratne RS, Crisanti A and Holder AA (2005) Disruption of a Plasmodium berghei Merozoite Surface Protein -7 gene modulates parasite growth in vivo. Blood. 105,394-6. Epub 2004 Aug 31.

5. Billker O, Dechamps S, Tewari R, Wenig G, Franke-Fayard B and Brinkmann V (2004) Calcium and a Calcium Dependent Protein Kinase Regulate Gamete Formation and Mosquito Transmission in a Malaria Parasite. Cell. 14,503-14.

6. Edvardsen RB, Lerat E, Maeland AD, Fla t M, Tewari R, Jensen MF, Lehrach H, Reinhardt R, Seo HC, Chourrout D(2004) Hypervariable and highly divergent intron-exon organizations in the chordate Oikopleura dioica. J. Mol. Evol. 59,448-57

7. Gillemans N, McMorrow T, Tewari R, Wai AW, Burgtorf C, Drabek D, Ventress N, Langeveld A, Higgs D, Tan-Un K, Grosveld F, and Philipsen S (2003) A functional and comparative analysis of globin loci in pufferfish and man. Blood 101, 2842-2849.

8. Tewari R, Spaccapelo R, Bistoni F, Holder AA and Crisanti A (2002) Function of Region I and II adhesive motifs of Plasmodium falciparum circumsporozoite protein in sporozoite motility and infectivity. J. Biol. Chem. 49, 47613-47618.

9. Kropf P, Herath S, Tewari R, Syed N, Klemenz R, Müller I (2002) Identification of two distinct subpopulations of Leishmania major-specific T helper 2 cells. Infect. Immun. 70, 5512-5520.

10. Gillemans N, Tewari R, Lindeboom F, Rottier R, de Wit T, Wijgerde M, Grosveld F and Philipsen S (1998) Altered DNA -binding specificity mutants of EKLF and Sp1 show that EKLF is an activator of -globin locus control region in vivo. Gen. & Dev.15, 2863-2873.

11. Tewari R, Gillemans N, Wijgerde M , Von Lindern M , Grosveld F and Philipsen S (1998) Erythroid Kruppel - like factor (EKLF) is active in primitive and definitive erythroid cells and is required for the function of 5’HS3 of -globin locus control region. EMBO 17, 2334-2341.

12. Tewari R, Gillemans N, Harper A, Wijgerde M , Zafarana G, Drabek , Grosveld F, and Philipsen S. (1996) The human -globin locus control region confers an early embryonic erythroid -specific expression pattern to a basic promoter driving the bacterial lacZ gene. Development 122, 3991-3999.

13. Ellis J, Philipsen S, Strouboulis J, Pruzina S, Tewari R, Gillemans N, Drabek, D, Harper A, Grosveld F and Fraser P (1995). The regulation of human  globin gene expression; the roles of 5’HS1-4. Proceedings of the Ninth Conference on Hemoglobin Switching held at Orcas Island, 10-14 June 1994, editor Dr. G. Stamatoyannopoulos, pg. 29-38

14. Nakayama I, Foresti F, Tewari R, Schartl M and Chourrout D (1994) Sex chromosome polymorphism and heterogametic males revealed by two cloned DNA probes in ZW/ZZ fish Leporinus elongatus. Chromosoma 103, 31-39.

15. Tewari R , Michard-Vanhee C, Perrot E and Chourrout D (1992) Mendelian transmission, structure and expression of transgenes following their injection into the cytoplasm of trout eggs. Transgenic Research 1, 250-260.

16. Tewari R and Rao SRV (1991) Replication status of the fragile X chromosome and its implications for reproductive performance in the Indian mole rat (Nesokia indica). J.Reprod. Fert. 91, 203-206.

17. Thelma BK, Tewari R, Juyal RC and Rao SRV (1991). Random/non random X-inactivation in Nesokia indica: possible influence of heterochromatin. Cytogen. Cell Gen. 56, 87-90.

18. Tewari R, Juyal RC, Rao SRV and Thelma BK (1989). Significance of fragile sites on the sex chromosome of Nesokia indica. Nucleus 32, 93-102.

19. Thelma BK, Juyal RC, Tewari R and Rao SRV (1988). Does heterochromatin potentiate speciation? A study in Nesokia. Cytogen. Cell Gen. 47, 204-208.

20. Tewari R, Juyal RC, Thelma BK, Das BC and Rao SRV (1987). Folate sensitive fragile sites on the X-chromosome heterochromation of the Indian mole rat, Nesokia indica, Cytogen. Cell Gen. 44, 11-17.

21. Simon MM, Ali S, Tewari R, Simon HG, Muller-Hermelink HK and EpplenJT (1986) Leukemic cells arise from cloned cytotoxic lymphocytes during cell culture. Eur. J. Immun. 16, 1269-1276.