Billker:Rita Tewari

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I am a Research Lecturer associated with the Billker Lab

Major research interest on "Functional analysis of malaria parasite-host cell interactions in vivo using gene targeting". Presentally working on a genome-wide systematic deletion analysis of Plasmodium berghei protein kinases to reveal molecular mechanisms of life cycle regulation.


my email: r.tewari[AT]imperial.ac.uk

Publications

  1. Coppi A, Tewari R, Bishop JR, Bennett BL, Lawrence R, Esko JD, Billker O, and Sinnis P. Heparan sulfate proteoglycans provide a signal to Plasmodium sporozoites to stop migrating and productively invade host cells. Cell Host Microbe. 2007 Nov 15;2(5):316-27. DOI:10.1016/j.chom.2007.10.002 | PubMed ID:18005753 | HubMed [Coppi2007]
  2. Raine JD, Ecker A, Mendoza J, Tewari R, Stanway RR, and Sinden RE. Female inheritance of malarial lap genes is essential for mosquito transmission. PLoS Pathog. 2007 Mar;3(3):e30. DOI:10.1371/journal.ppat.0030030 | PubMed ID:17335349 | HubMed [Raine2007]
  3. Escaron CJ, Lees DM, Tewari R, Smith DF, and Caron E. A simple, robust and versatile method to characterise intracellular parasitism. Mol Biochem Parasitol. 2007 May;153(1):72-6. DOI:10.1016/j.molbiopara.2007.01.008 | PubMed ID:17303261 | HubMed [Escaron2007]
  4. Tewari R, Dorin D, Moon R, Doerig C, and Billker O. An atypical mitogen-activated protein kinase controls cytokinesis and flagellar motility during male gamete formation in a malaria parasite. Mol Microbiol. 2005 Dec;58(5):1253-63. DOI:10.1111/j.1365-2958.2005.04793.x | PubMed ID:16313614 | HubMed [Tewari2005a]
  5. Reininger L, Billker O, Tewari R, Mukhopadhyay A, Fennell C, Dorin-Semblat D, Doerig C, Goldring D, Harmse L, Ranford-Cartwright L, Packer J, and Doerig C. A NIMA-related protein kinase is essential for completion of the sexual cycle of malaria parasites. J Biol Chem. 2005 Sep 9;280(36):31957-64. DOI:10.1074/jbc.M504523200 | PubMed ID:15970588 | HubMed [Reininger2005]
  6. Tewari R, Rathore D, and Crisanti A. Motility and infectivity of Plasmodium berghei sporozoites expressing avian Plasmodium gallinaceum circumsporozoite protein. Cell Microbiol. 2005 May;7(5):699-707. DOI:10.1111/j.1462-5822.2005.00503.x | PubMed ID:15839899 | HubMed [Tewari2005b]
  7. Tewari R, Ogun SA, Gunaratne RS, Crisanti A, and Holder AA. Disruption of Plasmodium berghei merozoite surface protein 7 gene modulates parasite growth in vivo. Blood. 2005 Jan 1;105(1):394-6. DOI:10.1182/blood-2004-06-2106 | PubMed ID:15339842 | HubMed [Tewari2005c]
  8. Billker O, Dechamps S, Tewari R, Wenig G, Franke-Fayard B, and Brinkmann V. Calcium and a calcium-dependent protein kinase regulate gamete formation and mosquito transmission in a malaria parasite. Cell. 2004 May 14;117(4):503-14. PubMed ID:15137943 | HubMed [Billker2004]
  9. Edvardsen RB, Lerat E, Maeland AD, Flåt M, Tewari R, Jensen MF, Lehrach H, Reinhardt R, Seo HC, and Chourrout D. Hypervariable and highly divergent intron-exon organizations in the chordate Oikopleura dioica. J Mol Evol. 2004 Oct;59(4):448-57. DOI:10.1007/s00239-004-2636-5 | PubMed ID:15638456 | HubMed [citation6]
  10. Gillemans N, McMorrow T, Tewari R, Wai AW, Burgtorf C, Drabek D, Ventress N, Langeveld A, Higgs D, Tan-Un K, Grosveld F, and Philipsen S. Functional and comparative analysis of globin loci in pufferfish and humans. Blood. 2003 Apr 1;101(7):2842-9. DOI:10.1182/blood-2002-09-2850 | PubMed ID:12517812 | HubMed [Gillemans2003]
  11. Tewari R, Spaccapelo R, Bistoni F, Holder AA, and Crisanti A. Function of region I and II adhesive motifs of Plasmodium falciparum circumsporozoite protein in sporozoite motility and infectivity. J Biol Chem. 2002 Dec 6;277(49):47613-8. DOI:10.1074/jbc.M208453200 | PubMed ID:12244064 | HubMed [Tewari2002]
  12. Kropf P, Herath S, Tewari R, Syed N, Klemenz R, and Müller I. Identification of two distinct subpopulations of Leishmania major-specific T helper 2 cells. Infect Immun. 2002 Oct;70(10):5512-20. PubMed ID:12228277 | HubMed [Kropf2002]
  13. Gillemans N, Tewari R, Lindeboom F, Rottier R, de Wit T, Wijgerde M, Grosveld F, and Philipsen S. Altered DNA-binding specificity mutants of EKLF and Sp1 show that EKLF is an activator of the beta-globin locus control region in vivo. Genes Dev. 1998 Sep 15;12(18):2863-73. PubMed ID:9744863 | HubMed [Gillemans1998]
  14. Tewari R, Gillemans N, Wijgerde M, Nuez B, von Lindern M, Grosveld F, and Philipsen S. Erythroid Krüppel-like factor (EKLF) is active in primitive and definitive erythroid cells and is required for the function of 5'HS3 of the beta-globin locus control region. EMBO J. 1998 Apr 15;17(8):2334-41. DOI:10.1093/emboj/17.8.2334 | PubMed ID:9545245 | HubMed [Tewari1998]
  15. Tewari R, Gillemans N, Harper A, Wijgerde M, Zafarana G, Drabek D, Grosveld F, and Philipsen S. The human beta-globin locus control region confers an early embryonic erythroid-specific expression pattern to a basic promoter driving the bacterial lacZ gene. Development. 1996 Dec;122(12):3991-9. PubMed ID:9012519 | HubMed [Tewari1996]
  16. Ellis J, Philipsen S, Strouboulis J, Pruzina S, Tewari R, Gillemans N, Drabek, D, Harper A, Grosveld F and Fraser P (1995). The regulation of human  globin gene expression; the roles of 5’HS1-4. Proceedings of the Ninth Conference on Hemoglobin Switching held at Orcas Island, 10-14 June 1994, editor Dr. G. Stamatoyannopoulos, pg. 29-38 [citation13]
  17. Nakayama I, Foresti F, Tewari R, Schartl M, and Chourrout D. Sex chromosome polymorphism and heterogametic males revealed by two cloned DNA probes in the ZW/ZZ fish Leporinus elongatus. Chromosoma. 1994 Mar;103(1):31-9. PubMed ID:8013252 | HubMed [Nakayama1994]
  18. Tewari R , Michard-Vanhee C, Perrot E and Chourrout D (1992) Mendelian transmission, structure and expression of transgenes following their injection into the cytoplasm of trout eggs. Transgenic Research 1, 250-260. [citation15]
  19. Tewari R and Rao SR. Replication status of the fragile X chromosome and its implications for reproductive performance in the Indian mole rat (Nesokia indica). J Reprod Fertil. 1991 Jan;91(1):203-6. PubMed ID:1995848 | HubMed [Tewari1991]
  20. Thelma BK, Tewari R, Juyal RC, and Rao SR. Random/nonrandom X-chromosome inactivation in Nesokia indica: possible influence of heterochromatin. Cytogenet Cell Genet. 1991;56(2):87-90. PubMed ID:2013237 | HubMed [Thelma1991]
  21. Tewari R, Juyal RC, Rao SRV and Thelma BK (1989). Significance of fragile sites on the sex chromosome of Nesokia indica. Nucleus 32, 93-102. [citation18]
  22. Thelma BK, Juyal RC, Tewari R, and Rao SR. Does heterochromatin variation potentiate speciation? A study in Nesokia. Cytogenet Cell Genet. 1988;47(4):204-8. PubMed ID:3416654 | HubMed [Thelma1988]
  23. Tewari R, Juyal RC, Thelma BK, Das BC, and Rao SR. Folate-sensitive fragile sites on the X-chromosome heterochromatin of the Indian mole rat, Nesokia indica. Cytogenet Cell Genet. 1987;44(1):11-7. PubMed ID:3816302 | HubMed [Tewari1987]
  24. Simon MM, Ali S, Tewari R, Simon HG, Müller-Hermelink HK, and Epplen JT. Leukemic cells arise from cloned cytotoxic lymphocytes during cell culture. Eur J Immunol. 1986 Oct;16(10):1269-76. DOI:10.1002/eji.1830161014 | PubMed ID:3095125 | HubMed [Simon1986]
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