Difference between revisions of "AhmadWeek5"

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(trouble with reactome)
(added reactome pathway)
 
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==Reactome==
 
==Reactome==
I am unable to load the Reactome website. I can use the links at the top, but the search is not working either. Not sure what to do...
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[[Image:ReactomePathwayAhmad.jpg]]
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[http://www.reactome.org/entitylevelview/PathwayBrowser.html#DB=gk_current&FOCUS_SPECIES_ID=68322&FOCUS_PATHWAY_ID=2666285&ID=2659868&VID=6541595 Reactome Source]
  
 
{{Salman Ahmad}}
 
{{Salman Ahmad}}

Latest revision as of 22:54, 14 February 2013

Saccharomyces Genome Database

  1. Which of these genes has a homolog (similar gene related by descent) in humans? What disease does a deficiency of this gene cause in humans?
    • GDH2; the homologs are GLUD1 and GLUD2. "Deficiencies in the human homologs of glutamate dehydrogenase, GLUD1 and GLUD2, have been linked to hyperinsulinism-hyperammonemia syndrome and various neurological disorders." GDH2
  2. How is the expression of each of these genes regulated?
    • GDH1- Expression is "regulated by nitrogen and carbon sources" GDH1
    • GDH3- Expression is "regulated by nitrogen and carbon sources" GDH3
    • GDH2- Expression is "sensitive to nitrogen catabolite repression and intracellular ammonia levels" GDH2
    • GLN1- Expression is "regulated by nitrogen source and by amino acid limitation" GLN1
    • GLT1- Expression is "regulated by nitrogen source" GLT1
  3. "L-glutamate". How many pathways does it participate in?
    • It is in reactions as a reactant 26 times. It is in reactions as a product 29 times. L-glutamate

LglutamatePathway.gif Pathway Image Source

Kegg

KeggPathway.jpg Pathway Image Source

  • Kegg shows both the full amino acid sequence and full nucleotide sequence when you click on the enzyme name. SGD did not show this.

Reactome

ReactomePathwayAhmad.jpg Reactome Source

Assignments

Useful links