INTERACTOMICS & BIOLOGICAL NETWORKS
Oxford Bioinformatics Volume 22 | Number 17 | 1 September 2006
- Constructing biological networks through combined literature mining and microarray analysis: a LMMA approach
Network representation of biological entities is very important for understanding biological processes, system organization and interaction between entities. Shao Li et al. integrated both the literatures and microarray gene-expression data, and developed a combined literature mining and microarray analysis (LMMA) approach to construct gene networks of a specific biological system. In the LMMA approach, a global network is first constructed using the literature-based co-occurrence method. It is then refined using microarray data.
This work may be a start towards an Integrated Biological Network representation where different data sets from literature, genomics and proteomics will be used to give precise and useful multidimensional interaction networks.