6.021/Notes/2006-10-27

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Hodgkin-Huxley

  • assumed conductances on depend on membrane potential and not concentrations
    • used this to determine contribution of Na and K currents by fixing membrane potential and changing concentrations which affect Nernst potentials only
  • persistent current primarily due to K
  • transient current due to Na
  • is constant for (step in potential). Same for K
    • Thus conductances are simply scaled versions of the current
    • Fit the current responses using following parameters
  • where
  • where
  • and are activating functions
    • are about 0 at negative and has asymptote 1
  • is the reverse. =1 for low and 0 for high
  • (time constant for activating Na) is much smaller than other time constants