Revision as of 02:12, 29 November 2012
20.109(F12) Pre-Proposal: Degrading biofilms by engineered enzymatic bacteriophage via functionalized graphene
Bacterial biofilms, composed of microorganisms embedded in a matrix of extracellular polymeric substances (EPS), exhibit antibiotic resistance, presenting a problem in controlling biofilm-associated clinical infections. Previous research on biofilm control has shown phage therapy to be effective in disrupting the biofilm[ref]. We propose to use modified graphene oxide (GO) as a carrier to facilitate the delivery of engineered bacteriophages in order to improve the degradation of biofilms.
ONE PARAGRAPH and at least TWO REFERENCES
- What is known about this field
- Why is this field important
Make clear what you see is the structural hole/gap in understanding or the need, and how you propose to fill in or satisfy what you've identified. You should specify your general approach (e.g. "will screen for mutants that enhance the contrast of the bacterial photography system") but do not need to think through the precise experimental details yet. Emphasize instead what results hope to collect and how they might improve the shortcomings that you've identified as interesting.