CH391L/S13/In vitro Selection of FNAs: Difference between revisions

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Functional nucleic acids (FNAs, as described by Dr. S.K. Silverman, are DNA and RNA aptamers that bind targets, or they are deoxyribozymes (single stranded DNA) and ribozymes (RNA) that have catalytic activity. Aptamers, Ribozymes, and Deoxyribozymes are grouped into three main categories that are further classified into either natural or artificial depending on their origin. The exception being Deoxyribozymes as they have yet to be discovered in a living organism. Although the first ribozyme was discovered only in the 1980s, the search for new and better FNAs continues. This has led the discovery of new methods, such as the SELEX <cite>Stozack1990, Gold1990 </cite> or ''In vitro'' selection process, as we strive to their potential both as tools for exploring biology and solving real world problem solving.

[[Image:FNA Chronology.png|center|thumb|800px|Functional Nucleic Acid Chronology <cite>~~Ellington1990~~, Gold1990</cite>,<cite>Cech1982</cite>,<cite>Altman1983</cite>,<cite>Ellington1990</cite>,<cite>BreakerJoyce1994</cite>,<cite>Wrinkler2002</cite>. ]]

[[Image:FNA Chronology.png|center|thumb|800px|Functional Nucleic Acid Chronology <cite>Stozack1990, Gold1990</cite>,<cite>Cech1982</cite>,<cite>Altman1983</cite>,<cite>Ellington1990</cite>,<cite>BreakerJoyce1994</cite>,<cite>Wrinkler2002</cite>. ]]

==Functional Nucleic Acids==

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 Functional nucleic acids (FNAs, as described by Dr. S.K. Silverman, are DNA and RNA aptamers that bind targets, or they are deoxyribozymes (single stranded DNA) and ribozymes (RNA) that have catalytic activity. Aptamers, Ribozymes, and Deoxyribozymes are grouped into three main categories  that are further classified into either natural or artificial depending on their origin. The exception being Deoxyribozymes as they have yet to be discovered in a living organism. Although the first ribozyme was discovered only in the 1980s,  the search for new and better FNAs continues. This has led the discovery of new methods, such as the SELEX <cite>Stozack1990, Gold1990 </cite> or ''In vitro'' selection process, as we strive to their potential both as tools for exploring biology and solving real world problem solving.
-[[Image:FNA Chronology.png|center|thumb|800px|Functional Nucleic Acid Chronology <cite>Ellington1990, Gold1990</cite>,<cite>Cech1982</cite>,<cite>Altman1983</cite>,<cite>Ellington1990</cite>,<cite>BreakerJoyce1994</cite>,<cite>Wrinkler2002</cite>. ]]
+[[Image:FNA Chronology.png|center|thumb|800px|Functional Nucleic Acid Chronology <cite>Stozack1990, Gold1990</cite>,<cite>Cech1982</cite>,<cite>Altman1983</cite>,<cite>Ellington1990</cite>,<cite>BreakerJoyce1994</cite>,<cite>Wrinkler2002</cite>. ]]
 ==Functional Nucleic Acids==