User talk:Pomijekl
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Abstract
Microbial biotechnology has been essential in the development and improvement of human growth hormones. This page and project are dedicated to detailed study and research about the technology involved in human growth hormone development, products and services, why microbes are important, the scientific approach, the market for these products, impacts and potential impacts, associated risks, and ethical issues.
State of the Art
As noted by the United States Department of Agriculture, the use of microbial biotechnology has and will lead to breakthroughs in many fields, including pharmaceuticals. The use of microbial biotechnology in the creation of human growth hormones is not new or foreign to the field of biotechnology, but it is constantly in a state of progress and evolution. Prior to the use of recombinant DNA, human growth hormones necessary to help individuals with diseases such as hypopituitarism were obtained only from the pituitary glands of human cadavers. This, naturally, had many negative implications. Because so many pituitary glands were necessary to create the needed supply of human growth hormones, there were incredible shortages. The first commercially available human growth hormone made using microbial biotechnology was produced in 1985 by scientists at Genetech. This led to possible production of an almost endless supply of this very vital pharmaceutical.
Objectives
Due to past complications with biological (corpse) growth hormone, we sought alternative hormone production options to be used in the treatment of Hypopituitarism. In our research we read about more recent treatments with the use of Somatropin, a synthetic human growth hormone. Again there were a list of side effects and other issues. We are now looking at protein secretion technology, a purer and more stable method, as a way to manufacture the hormones and reduce side effects.
Scientific Approach
Methods
Alternative Methods
(Potential) Impact
Associated Risks
Side Effects For Somatropin Injection
Red welts, painful injection spots, and increased site temperature are indicative of an immune response to GH injections.
Human Growth Hormone Side Effects
Joint Pain; because of its ability to cause growth in a person’s body, some users report joint pain while taking HGH. This side effect is usually temporary. Generally, over-stimulation of non-target organs leads to unwanted side effects.
Ethical Issues
One of the current top concerns for hormone treatment is the cost. Growth hormone is one of the most expensive treatments in all medical fields. Are there alternative ways to produce the same product for less?
References
Scientific articles
Weblinks
- Microbial Biotechnology. United States Department of Agriculture: Cooperative State Research, Education, and Extension Service. September 6, 2006 <http://www.csrees.usda.gov/nea/biotech/in_focus/biotechnology_if_microbial.html>
- Human Growth Hormone
<http://www.humangrowthhormone.me.uk/protein-secreation-technology.htm> <http://www.humangrowthhormone.me.uk/antibodies.htm>
- Hypopituitarism.University of Maryland Medical Center(UMMC), 2006
