User:Yiannis Kaznessis

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Contact Info

• Yiannis Kaznessis
• Department of Chemical Engineering and Materials Science
• University of Minnesota
• 421 Washington Ave SE
• Minneapolis, MN 55455, USA
• Email me through OpenWetWare

In my group we are interested in computational synthetic biology. We are developing the Synthetic Biology Software Suite, a publicly available software suite that assists in rationally designing synthetic gene regulatory networks. We combine components from BioBricks to generate networks of biomolecular reactions. We combine stochastic-discrete, stochastic-continuous and continuous-deterministic models to simulate these reaction networks. Version 1.0.2 is available on Sourceforge.net [1]. We are now incorporating the connection with BioBricks.

In recent work (Ramalingam, KI, Tomshine, JR, Maynard, JA, Kaznessis YN. " Forward engineering of synthetic bio-logical AND gates" Biochemical Engineering Journal, 2009, 47(1-3):38-47), we used multiscale models of gene regulatory networks to design, build and test bio-logical AND gates.

We are also participating in the iGEM competition. We were awarded a Gold Medal in 2009 for SynBioSS work.

Education

• 1999, PhD, University of Notre Dame
• 1994, BS, Aristotle University in Thessaloniki

Research interests

1. Statistical mechanics (yes, it can be fun!)
2. Synthetic biology
3. Computer simulations

Computational Synthetic Biology Publications

1. Kaznessis YN. . pmid:19830714. PubMed HubMed [Paper10]
2. Sotiropoulos V, Contou-Carrere MN, Daoutidis P, and Kaznessis YN. . pmid:19644174. PubMed HubMed [Paper11]
3. Hill AD, Tomshine JR, Weeding EM, Sotiropoulos V, and Kaznessis YN. . pmid:18757873. PubMed HubMed [Paper12]
4. Kaznessis YN. . pmid:17986347. PubMed HubMed [Paper1]
5. Sotiropoulos V and Kaznessis YN. . pmid:18190181. PubMed HubMed [Paper2]
6. Sotiropoulos V and Kaznessis YN. . pmid:17408514. PubMed HubMed [Paper3]
7. Salis H and Kaznessis YN. . pmid:17200605. PubMed HubMed [Paper4]
8. Tomshine J and Kaznessis YN. . pmid:16920827. PubMed HubMed [Paper5]
9. Salis H, Sotiropoulos V, and Kaznessis YN. . pmid:16504125. PubMed HubMed [Paper6]
10. Salis H and Kaznessis YN. . pmid:16356038. PubMed HubMed [Paper7]
11. Salis H and Kaznessis Y. . pmid:15740306. PubMed HubMed [Paper8]
12. Tuttle LM, Salis H, Tomshine J, and Kaznessis YN. . pmid:16183880. PubMed HubMed [Paper9]

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