User:Thomas J. Rosol

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Thomas J. Rosol
Thomas J. Rosol
  • Thomas J. Rosol, DVM, PhD
  • Professor of Veterinary Biosciences
  • Special Assistant to the Senior Vice President for Technology Licensing & Commercialization
  • Diplomate, American College of Veterinary Pathologists
  • College of Veterinary Medicine
  • The Ohio State University
  • 1925 Coffey Road
  • Columbus, OH 43210 USA
  • College webpage: http://www.vet.ohio-state.edu/ThomasRosol.htm
  • Curriculum vitae and publications: http://myprofile.cos.com/rosolt36
  • Email: rosol.1@osu.edu

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Education

  • Ph.D., Ohio State University, Experimental Pathobiology, 1986
  • D.V.M., University of Illinois, Veterinary Medicine (Valedictorian, 1st of 86 Students), 1981
  • B.S., University of Illinois, Veterinary Medicine (Highest Honors), 1979
  • B.S., University of Illinois, Agricultural Science (Highest Honors), 1978

Biography

  • See: http://myprofile.cos.com/rosolt36
  • Thomas J. Rosol, DVM, PhD served as the Dean of the College of Veterinary Medicine (2005-2008) and currently serves as a Special Assistant to the Senior Vice President for Research for Technology Licensing and Commercialization. He is a Professor of Veterinary Pathobiology in the Department of Veterinary Biosciences in the OSU College of Veterinary Medicine.
  • Dr. Rosol maintains an active, NIH-funded research laboratory that uses molecular, in vitro, and in vivo techniques to investigate the pathogenesis of human and animal cancers. Specifically, the laboratory develops mouse models of cancer to study the pathogenesis of bone metastasis, cancer-associated hypercalcemia, and human HTLV-1-induced T-cell lymphoma. The molecular regulation of parathyroid hormone-related protein is studied in vitro and in vivo using animal models of prostate, lung, and breast cancer, and lymphoma. Breast and prostate cancer both metastasize to bone in humans, but breast cancer typically induces osteolytic disease and prostate cancer typically induces osteoblastic metastases. The Rosol laboratory has developed mouse models of human cancer that mimic metastases in humans and are used to investigate the pathogenesis and treatment of metastasis. New laboratory expertise has been developed for in vivo imaging of cancer in mouse models using bioluminescence, high resolution ultrasound, and near infrared imaging of molecular markers. The lab is also examining the ability of nanoparticles to enhance the ultrasound imaging of cancer molecular markers.

Research interests

  • PARATHYROID HORMONE-RELATED PROTEIN (PTHrP):
 Pathogenesis in humoral hypercalcemia of malignancy
 Regulation in normal and neoplastic keratinocytes
 Regulation in lactation and mammary carcinomas
 Development of PTHrP knockout and knockin Mice
 Regulation of mRNA expression and stability
 Role in cancer metastases in bone
 Role in bone resorption associated with Human T-Lymphotropic-I Virus infection and canine lymphoma
 Regulation of PTHrP mRNA expression by Tax and HTLV-1 virus 
  • ANIMAL MODELS OF HUMAN DISEASE:
 Paraneoplastic Syndromes
 Endocrinology
 Bone Disease, Bone Remodeling, Bone Metastasis
 Prostate Cancer and Osteoblastic Metastasis
 Breast, Lung, and Head & Neck Cancer and Osteolytic Bone Metastasis

Publications

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