User:Sim Huay Ping/Notebook/CBE/08/150

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Efficacy testing of antimicrobial peptides against bacteria

Cationic antimicrobial peptides (AMPs) are indispensible components of innate immune systems and promising candidates for novel anti-infective strategies. Engineered and natural AMPs are reviewed and their efficacy against bacteria will be analysed. Innate immunity is the basic resistance to diseases that all living things possess, and AMPs is one of the components of host-defense. AMPs are effective against various pathogenic microorganisms including gram positive and gram negative bacteria, fungi, yeasts and viruses. AMPs can kill target cells through diverse mechanisms like inhibition of cell wall formation, formation of pores in the cell membrane resulting in membrane depolarisation and eventually lysis of the cell, inhibition of nuclease activity involving DNA and RNA.

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