User:Shahzad Nawaz Syed
Phone: +49 941 944 7342
Fax: +49 941 944 7341
Department of Internal Medicine II
University Hospital Regensburg
The lab belongs to Department of Internal Medicine II, headed by Prof. Mattias Mack in UniversitatsKlinikum Regensburg.
Summary of Education
- 2009, PhD in Molecular Immunology, PhD Program 'Molecular Medicine', Hannover Biomedical Research School, Medizinische Hochschule Hannover, Germany
- 2002, MSc in Biochemistry, PG Department of Biochemistry, Nagpur University, India
- 2000, MSc-I in Botany (Cytology and Genetics), PG Department of Botany, Nagpur University, India
- 1999, BSc in Biochemistry, Chemistry and Botany, St Francis de Sales College, Nagpur University, India
- The focus of the lab is to decipher the role of different immune cells in disease and pathology at molecular level. We are also interested to understand how chemokine receptors participate in inflammatory diseases. Ontogeny and migration of inflammatory cells to the site of infection and inflammation is another area in which are keen to persue our research. The ultimate goal of our research is to develop a tool for clinical application.
- Previously, we have demostrated that in addition to antigen-specific B-cells, Basophilic granulocytes are the only other leukocyte that binds significant amounts of intact antigens on the cell surface. This binding is detectable even in a non-dominated allergic immune response. We also found that activated basophils granulocytes influence the activation of T-cells and the Th1 / Th2 differentiation. Due to the higher expression of CCR2 on basophils granulocytes and our preliminary data suggest the immunoregulatory role of CCR2 in the model of collagen-induced arthritis, we assume that basophils granulocytes paly a role in inflammatory diseases and possibly in the transplant rejection, an unrecognized importance in the regulation of humoral and cellular immune responses. With the help of in vitro and in vivo studies we are currently investigating the influence of granulocytes on the T and B-cell activation and identification of the responsible mediators.
- 2010-present: Post Doctoral Scientist, Laboratory of Molecular Immunology, Department of Internal Medicine II, Universitatsklinikum Regensburg, Germany
- 2005-2009: PhD Fellow, Laboratory of Molecular Immunology, Clinic for Immunology and Rheumatology, PhD Program 'Molecular Medicine', Medizinische Hochschule Hannover, Germany
- 2002-2005: Research Associate, Insect Biochemistry and Molecular Biology Laboratory, Central Institute for Cotton Research, Nagpur, India
- 1999-2001: Senior Systems Adminstrator, IQ Infosystems Ltd. Nagpur, India
- 1998-1998: Junior Assistant, Institute of Genetics Studies, Nagpur, India.
- Syed SN, Konrad S, Wiege K, Schmidt RE and Gessner JE. 2008. Both FcRIV and FcRIII are essential receptors mediating type II and type III autoimmune responses via FcR-LAT dependent generation of C5a. Eur J Immunol. 39(12):3343-56.
- Braun A, Gessner JE, Varga-Szabo D, Syed SN, Konrad S, Stegner D, Vögtle T, Schmidt RE, Nieswandt B. 2009. STIM1 is essential for Fcgamma receptor activation and autoimmune inflammation. Blood 113(5):1097-104.
- Konrad S, Ali SR, Wiege K, Syed SN, Engling L, Piekorz RP, Hirsch E, Nürnberg B, Schmidt RE, Gessner JE. 2008. Phosphoinositide 3-kinases gamma and delta, linkers of coordinate C5a receptor-Fcgamma receptor activation and immune complex-induced inflammation.J Biol Chem. 283(48):33296-303.
- Kranthi S, Kranthi KR, Bharose AA, Syed SN, Patil EK and Mayee CD. 2006. Comparison of Partial COI sequences of two Helicoverpa (Noctuidae: Lepidoptera) species in India. Indian J. Biotechnology 5:195-199.
- Jha H, Syed SN, Parkhi V, Bhandarkar MR, and Patil M. 2005. Comparative Biochemical and RAPD-PCR Analysis of Ligninolytic Fungi Penicillium oxalicum and Phanerochaete chrysosporium. Asian Jr. of Microbiol. Biotech. & Env.Sc. 7(3) 569-575
- Kranthi S, Kranthi KR, Bharose AA and Syed SN. 2005. PCR-RFLP based method for differentiating two species of Helicoverpa. Current Science 89 (8) 1322-1323.