Matt Gethers

From OpenWetWare

I'm currently a sophomore in course 20. When I'm behaving myself, I'm allowed to work in the Endy Lab at MIT. I have links to my UROP projects and 20.109 work directly below.

UROP Projects

Articles of General Interest

Translation Demand

Mitochondrial Engineering

CRI Thailand

OWW Syntax

20.109 Work

• M13 Engineering Ideas

• 2.27.06 Ligation and Transformation Data

• 2.27.09 Refactoring Work

• 4.3.07_Primer_Design_Team_Purple.doc

• Research Proposal

Class projects

20.310 Term Paper

20.310 Project

1. Galkin O, Pan W, Filobelo L, Hirsch RE, Nagel RL, and Vekilov PG. Two-step mechanism of homogeneous nucleation of sickle cell hemoglobin polymers. Biophys J 2007 Aug 1; 93(3) 902-13. doi:10.1529/biophysj.106.103705 pmid:17449671. PubMed HubMed [Galkin]
2. Carragher B, Bluemke DA, Gabriel B, Potel MJ, and Josephs R. Structural analysis of polymers of sickle cell hemoglobin. I. Sickle hemoglobin fibers. J Mol Biol 1988 Jan 20; 199(2) 315-31. pmid:3351926. PubMed HubMed [Carragher]
3. Bluemke DA, Carragher B, Potel MJ, and Josephs R. Structural analysis of polymers of sickle cell hemoglobin. II. Sickle hemoglobin macrofibers. J Mol Biol 1988 Jan 20; 199(2) 333-48. pmid:3351927. PubMed HubMed [Carragher2]
4. Carragher B, Bluemke DA, Becker M, McDade WA, Potel MJ, and Josephs R. Structural analysis of polymers of sickle cell hemoglobin. III. Fibers within fascicles. J Mol Biol 1988 Jan 20; 199(2) 383-8. pmid:3351930. PubMed HubMed [Carragher3]
5. Jones CW, Wang JC, Ferrone FA, Briehl RW, and Turner MS. Interactions between sickle hemoglobin fibers. Faraday Discuss 2003; 123 221-36; discussion 303-22, 419-21. pmid:12638863. PubMed HubMed [Turner]
6. Wang JC, Turner MS, Agarwal G, Kwong S, Josephs R, Ferrone FA, and Briehl RW. Micromechanics of isolated sickle cell hemoglobin fibers: bending moduli and persistence lengths. J Mol Biol 2002 Jan 25; 315(4) 601-12. doi:10.1006/jmbi.2001.5130 pmid:11812133. PubMed HubMed [Wang]

Treatments exist for preventive and palliative treatment of sickle cell episodes, but no treatment has yet been developed to mitigate the effects of an attack once it has started. We need a way of dealing with Hbs fibers once they have polymerized. We feel we can develop a treatment for an ongoing attack by addressing the biomechanical basis of the pathology.