User:Galen Loving

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Galen Loving (an artistic interpretation)
Galen Loving (an artistic interpretation)

Galen Loving

Postdoctoral Research Fellow
Martinos Center for Biomedical Imaging
Massachusetts General Hospital
Harvard Medical School
[Contact information]
Postdoctoral mentor: Peter Caravan


Education

Ph.D Organic Chemistry, Massachusetts Institute of Technology, 2009
Ph.D. Advisor: Barbara Imperiali [lab homepage]

B.S. Chemistry, University of Kansas, 2003


Research

My current research is focused on the development of new chemical tools for use in molecular imaging of various cancer types. Such tools are expected to aid in the early detection of malignancies as well as offer more powerful means of monitoring and evaluating a patient’s response to different therapeutic treatments. Imaging modalities of interest include MRI, PET and fluorescence.


Publications

“A Versatile Amino Acid Analogue of the Solvatochromic Fluorophore 4-N,N-Dimethylamino-1,8-naphthalimide: A Powerful Tool for the Study of Dynamic Protein Interactions” Loving, G.S., Imperiali, B., J. Am. Chem. Soc., 2008, 130 (41), pp 13630–13638 [full text]

“Thiol-Reactive Derivatives of the Solvatochromic 4-N,N-Dimethylamino-1,8-naphthalimide Fluorophore: A Highly Sensitive Toolset for the Detection of Biomolecular Interactions” Loving, G.S., Imperiali, B., Bioconjugate Chem., 2009, 20 (11), pp 2133–2141 [full text]

“Monitoring protein interactions and dynamics with solvatochromic fluorophores” Loving, G.S., Sainlos, M., Imperiali, B., Trends Biotechnol., 2009, 28 (2), pp 73-83 [full text]

"Development of a fluorogenic sensor for activated Cdc42" Goguen, B.N., Loving, G.S., Imperiali, B. 2011, 21 (17), pp 5058–5061 [full text]

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