User:Etienne Robillard/Notebook/Endocannabinoids/Synopsis

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Synopsis

  • Key concept=Stimulation of endocannabinoid transport with polyunsaturated (22:6n-3) fatty acids (DHA, EPA) to target major depressive disorders (MDD) , epilepsy, amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS), posttraumatic stress disorder (PTSD), Parkinson's disease (PD), and Alzheimer's disease (AD).
  • Identification of CREB phosphorylation in the hippocampus promoting brain-derived neurotrophic factor (BDNF) expression, a molecular marker for learning-dependent synapse formation. [1] [2]
  • Intracellular CB1/BDNF signaling mediate on-demand neuroprotection on excitatory (glutamatergic) synapses and in particular astrocytes. [3]
    • DHA supplementation improves mitochondrial function and neuronal survival (homeostasis). [4]
  • Identification of a functional GPR40-GPR55 receptor heteromer with potent anti-inflammatory, antiglutamatergic and neuroprotective properties.
    • Anti-proliferative effects of DHEA on prostate cancer cell lines. [5]
    • A synaptogenic endocannabinoid promoting synaptogenesis.
    • Antioxidant (cytoprotective) properties of GPR40-GPR55 heteromer.
  • Effects of the endothelial CB2 receptor persistent activation on monocyte subpopulations/microglial activation. [6]
    • Anti-inflammatory role of anandamide and 2-AG signaling in LPS-stimulated microglial activation of endogenous CB2 receptor. [7]
    • Neuroprotection by inhibition of microglial activation. PMID PMID
    • CB2 stimulation is proneurogenic on adult hippocampal neurogenesis PMC
  • Caffeine is a adenosine antagonist which potentiate CB1 receptor activation in the hippocampus PMID PMID

References

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  1. Error fetching PMID 21035522: [Ludanyi-2011]
    Complementary synaptic distribution of enzymes responsible for synthesis and inactivation of the endocannabinoid 2-arachidonoylglycerol in the human hippocampus.

  2. Error fetching PMID 24360280: [Parkhurst-2013]
    Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor.

  3. Error fetching PMID 14526074: [Marsicano-2003]
    CB1 cannabinoid receptors and on-demand defense against excitotoxicity.

  4. Error fetching PMID 22248591: [Stanley-2012]
    Update on lipids and mitochondrial function: impact of dietary n-3 polyunsaturated fatty acids.

  5. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2930808/

    [Website2]

  6. Error fetching PMID 21350020: [Martin-Moreno-2011]
    Cannabidiol and other cannabinoids reduce microglial activation in vitro and in vivo: relevance to Alzheimer's disease.

  7. http://www.hindawi.com/journals/np/2015/130639/

    [Website1]

All Medline abstracts: PubMed HubMed
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