User:Elisabetta Lambertini/Notebook/Exposure-Response relationships

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Discussion on exposure-response relationships

(starter) Discussion on the applicability of various types of relationships between exposure and health outcome in QMRA. In particular, the comparison is between traditional human (or other animal) challenge studies, and relationships derived through epidemiological studies (e.g. in recreational water). Some topics to discuss further:

  • statistical basis of both types of relationships
  • cumulative exposure: scaling up in time daily exposure-response
  • assumptions of the study setting used to derive both types of curves
  • applicability of each types of curve to predict risk

Dose-response relationships from controlled feeding trials

Assumptions:

Requirements for applicability to other scenarios:


Exposure-response relationships from epidemiological studies

Examples: RWQ

Assumptions:

Requirements for applicability to other scenarios:

Going from one type of E-R to the other

consider: - single exposure - scaling up to multiple exposures over time - probability of illness vs. # cases - sources of variability (aka what matters most)

Notes

  • This project stems from the EPA-funded WAHTER (Water And Health Trial for Enteric Risk) study.


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