User:David Breslow

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Contact Info

I work in Max Nachury's lab at Stanford University.

Education

  • 2010, PhD, University of California, San Francisco. Advisor: Prof. Jonathan S. Weissman
  • 2004, A.B., Harvard University

Research interests

I'm investigating the role of primary cilia in signal transduction. In particular, I'm studying how the dynamic entry and exit of proteins from this organelle is coupled to its unique role in organizing signaling pathways.

Publications

• Roelants F.M.*, Breslow D.K.*, Muir A., Bodenmiller B., Weissman J.S., Thorner J.T. Control of sphingolipid homeostasis: Protein Kinase Ypk1 Regulates Orm1 and Orm2. Proc. Natl. Acad. Sci. USA, in press.

• Seo S., Zhang Q., Bugge K., Breslow D.K., Searby C.C., Nachury M.V., Sheffield V.C. A novel protein LZTFL1 regulates ciliary trafficking of the BBSome and Smoothened. PLoS Genetics. 7(11): e1002358. link

Breslow D.K. and Nachury M.V., (2011). Primary Cilia: How to Keep the Riff-Raff in the Plasma Membrane. Current Biology. 21(11): R434-436. link

Breslow D.K. and Weissman J.S., (2010). Membranes in Balance: Mechanisms of Sphingolipid Homeostasis. Molecular Cell. 40(2): 267-279. [review article]. link

Breslow D.K., Collins S.R., Bodenmiller B., Aebersold R., Simons K., Shevchenko A., Ejsing C.S., Weissman J.S., (2010). Orm Family Proteins Mediate Sphingolipid Homeostasis. Nature. 463(7284): 1048-1053. link

Breslow D.K.*, Cameron D.M.*, Collins S.R., Schuldiner M., Stewart-Ornstein J., Newman H.W., Braun S., Madhani H.D., Krogan N.J., Weissman J.S., (2008). A Comprehensive Strategy Enabling High-Resolution Functional Analysis of the Yeast Genome. Nature Methods. 5(8): 711-718. link

• Newman J.R., Ghaemmaghami S., Ihmels J., Breslow D.K., Noble M., DeRisi J.L., Weissman J.S. (2006). Single-cell Proteomic Analysis of S. cerevisiae Reveals the Architecture of Biological Noise. Nature, 441(7095): 840-846. link

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