User:Daniel M Jordan
I am a new member of OpenWetWare!
- Daniel M Jordan
- Graduate Student in Biophysics
- Laboratory of Shamil R. Sunyaev
- Division of Genetics, Department of Medicine
- Brigham and Women's Hospital and Harvard Medical School
- Email me through OpenWetWare
- 2006, BA Physics & Philosophy, Yale University
My main interest is in modeling the relationship between protein structures and evolutionary processes. To briefly summarize: in principle, molecular biology tells us that most functional mutations should be functional because they modify the structure of a protein. Interpreting the functional effect of mutations based on their effects on protein structures has not been terribly fruitful so far -- the most successful methods use primarily phylogenetic information. One major area of my research involves attempting to develop protein structure based heuristics that can improve functional predictions for mutations. I have had some success with developing such heuristics for specific human diseases; see my paper in the Feb 2011 issue of AJHG, in which I and my colleagues develop a proof-of-concept predictor for a specific genetic disease. Another area of research, which I am just beginning on, is attempting to understand the forces that control the evolution of protein structures, and map out the constraints that evolution places on protein structures.
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