User:Daniel M Jordan
I am a new member of OpenWetWare!
Contact Info
- Daniel M Jordan
- Graduate Student in Biophysics
- Laboratory of Shamil R. Sunyaev
- Division of Genetics, Department of Medicine
- Brigham and Women's Hospital and Harvard Medical School
- Email me through OpenWetWare
Education
- 2006, BA Physics & Philosophy, Yale University
Research interests
My main interest is in modeling the relationship between protein structures and evolutionary processes. To briefly summarize: in principle, molecular biology tells us that most functional mutations should be functional because they modify the structure of a protein. Interpreting the functional effect of mutations based on their effects on protein structures has not been terribly fruitful so far -- the most successful methods use primarily phylogenetic information. One major area of my research involves attempting to develop protein structure based heuristics that can improve functional predictions for mutations. I have had some success with developing such heuristics for specific human diseases; see my paper in the Feb 2011 issue of AJHG, in which I and my colleagues develop a proof-of-concept predictor for a specific genetic disease. Another area of research, which I am just beginning on, is attempting to understand the forces that control the evolution of protein structures, and map out the constraints that evolution places on protein structures.
Publications
- Jordan DM, Kiezun A, Baxter SM, Agarwala V, Green RC, Murray MF, Pugh T, Lebo MS, Rehm HL, Funke BH, and Sunyaev SR. Development and validation of a computational method for assessment of missense variants in hypertrophic cardiomyopathy. Am J Hum Genet. 2011 Feb 11;88(2):183-92. DOI:10.1016/j.ajhg.2011.01.011 |
- Jordan DM, Ramensky VE, and Sunyaev SR. Human allelic variation: perspective from protein function, structure, and evolution. Curr Opin Struct Biol. 2010 Jun;20(3):342-50. DOI:10.1016/j.sbi.2010.03.006 |
- Jordan DM, Mills KM, Andricioaei I, Bhattacharya A, Palmo K, and Zuiderweg ER. Parameterization of peptide 13C carbonyl chemical shielding anisotropy in molecular dynamics simulations. Chemphyschem. 2007 Jun 25;8(9):1375-85. DOI:10.1002/cphc.200700003 |
