User:Christopher H. Kennedy

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Contact Info

Christopher H. Kennedy (an artistic interpretation)

• Christopher H. Kennedy, Ph.D., M.P.H.
• Lake Erie College of Osteopathic Medicine
• 1858 West Grandview Boulevard
• Erie, PA 16509-1025, USA
• Email me through OpenWetWare

I am the Director of the Cancer Biology Laboratory at the Lake Erie College of Osteopathic Medicine. I learned about OpenWetWare from an article in Scientific American, and I've joined because I'm a firm believer in the free exchange of scientific ideas. There are a number of projects that I have worked on over the years. However, a large amount of this work has not been published in scientific journals. Therefore, I am interested in sharing my ideas and unpublished data via OpenWetWare. I have a significant amount of experience in the field of Free Radical Biology. Therefore, I hope to be able to make a contribution to this field of science through this forum.

Education

• 1988, PhD, Louisiana State University, Baton Rouge, LA, USA (Major - Organic Chemistry; Minor - Biochemistry)
• 2003, MPH, University of North Carolina, Chapel Hill, NC, USA (Environmental Sciences)
• 1983, BS, Edinboro University of Pennsylvania, Edinboro, PA, USA (Chemistry)

Research interests

1. Molecular Markers of Oxidative Stress in Carcinogenesis
2. Role of Genomic Instability in Carcinogenesis
3. Effects of Complex Mixtures of Toxicants on Human Bronchial Epithelial Cells

Publications

1. Kennedy CH, Pryor WA, Winston GW, and Church DF. Hydroperoxide-induced radical production in liver mitochondria. Biochem Biophys Res Commun. 1986 Dec 30;141(3):1123-9. DOI:10.1016/s0006-291x(86)80160-7 |
2. Kennedy CH, Dyer JM, Church DF, Winston GW, and Pryor WA. Radical production in liver mitochondria by peroxidic tumor promoters. Biochem Biophys Res Commun. 1989 May 15;160(3):1067-72. DOI:10.1016/s0006-291x(89)80111-1 |
3. Kennedy CH, Winston GW, Church DF, and Pryor WA. Benzoyl peroxide interaction with mitochondria: inhibition of respiration and induction of rapid, large-amplitude swelling. Arch Biochem Biophys. 1989 Jun;271(2):456-70. DOI:10.1016/0003-9861(89)90296-8 |
4. Maples KR, Kennedy CH, Jordan SJ, and Mason RP. In vivo thiyl free radical formation from hemoglobin following administration of hydroperoxides. Arch Biochem Biophys. 1990 Mar;277(2):402-9. DOI:10.1016/0003-9861(90)90596-q |
5. Kennedy CH and Mason RP. A reexamination of the cytochrome P-450-catalyzed free radical production from a dihydropyridine. Evidence of trace transition metal catalysis. J Biol Chem. 1990 Jul 15;265(20):11425-8.
6. Rumyantseva GV, Kennedy CH, and Mason RP. Trace transition metal-catalyzed reactions in the microsomal metabolism of alkyl hydrazines to carbon-centered free radicals. J Biol Chem. 1991 Nov 15;266(32):21422-7.
7. Kennedy CH, Church DF, Winston GW, and Pryor WA. tert-Butyl hydroperoxide-induced radical production in rat liver mitochondria. Free Radic Biol Med. 1992;12(5):381-7. DOI:10.1016/0891-5849(92)90087-w |
8. Kennedy CH, Hatch GE, Slade R, and Mason RP. Application of the EPR spin-trapping technique to the detection of radicals produced in vivo during inhalation exposure of rats to ozone. Toxicol Appl Pharmacol. 1992 May;114(1):41-6. DOI:10.1016/0041-008x(92)90094-9 |
9. Kennedy CH, Cohen KB, Bechtold WE, Chang IY, Eidson AF, Dahl AR, and Henderson RF. Effect of dose on the metabolism of 1,1,2,2-tetrabromoethane in F344/N rats after gavage administration. Toxicol Appl Pharmacol. 1993 Mar;119(1):23-33. DOI:10.1006/taap.1993.1040 |
10. Kennedy CH, Bechtold WE, Chang IY, and Henderson RF. Effect of dose on the disposition of 2-ethoxyethanol after inhalation by F344/N rats. Fundam Appl Toxicol. 1993 Nov;21(4):486-91. DOI:10.1006/faat.1993.1124 |
11. Benson JM, Chang IY, Cheng YS, Hahn FF, Kennedy CH, Barr EB, Maples KR, and Snipes MB. Particle clearance and histopathology in lungs of F344/N rats and B6C3F1 mice inhaling nickel oxide or nickel sulfate. Fundam Appl Toxicol. 1995 Dec;28(2):232-44. DOI:10.1006/faat.1995.1164 |
12. Kennedy CH, Mitchell CE, Fukushima NH, Neft RE, and Lechner JF. Induction of genomic instability in normal human bronchial epithelial cells by 238Pu alpha-particles. Carcinogenesis. 1996 Aug;17(8):1671-6. DOI:10.1093/carcin/17.8.1671 |
13. Belinsky SA, Swafford DS, Middleton SK, Kennedy CH, and Tesfaigzi J. Deletion and differential expression of p16INK4a in mouse lung tumors. Carcinogenesis. 1997 Jan;18(1):115-20. DOI:10.1093/carcin/18.1.115 |
14. Hussain SP, Kennedy CH, Amstad P, Lui H, Lechner JF, and Harris CC. Radon and lung carcinogenesis: mutability of p53 codons 249 and 250 to 238Pu alpha-particles in human bronchial epithelial cells. Carcinogenesis. 1997 Jan;18(1):121-5. DOI:10.1093/carcin/18.1.121 |
15. Kennedy CH, Cueto R, Belinsky SA, Lechner JF, and Pryor WA. Overexpression of hMTH1 mRNA: a molecular marker of oxidative stress in lung cancer cells. FEBS Lett. 1998 Jun 5;429(1):17-20. DOI:10.1016/s0014-5793(98)00505-5 |
16. Jaiswal AS, Kennedy CH, and Narayan S. A correlation of APC and c-myc mRNA levels in lung cancer cell lines. Oncol Rep. 1999 Nov-Dec;6(6):1253-6. DOI:10.3892/or.6.6.1253 |
17. Catallo WJ, Kennedy CH, Henk W, Barker SA, Grace SC, and Penn A. Combustion products of 1,3-butadiene are cytotoxic and genotoxic to human bronchial epithelial cells. Environ Health Perspect. 2001 Sep;109(9):965-71. DOI:10.1289/ehp.01109965 |
18. Kennedy CH, Pass HI, and Mitchell JB. Expression of human MutT homologue (hMTH1) protein in primary non-small-cell lung carcinomas and histologically normal surrounding tissue. Free Radic Biol Med. 2003 Jun 1;34(11):1447-57. DOI:10.1016/s0891-5849(03)00176-x |

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