User:Brendan J. Hussey

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Contact Info

Brendan J. Hussey
Brendan J. Hussey
  • Brendan J. Hussey
  • Toronto Ontario, Canada.

I am currently a PhD student at the University of Toronto working in synthetic biology with Dr. David McMillen. I learned about OpenWetWare from iGEM and Andrew Hessel, and I've joined because competing in iGEM secured strong interest in synthetic biology. Ever since I have been optimistic for the future of synthetic biology and it has dominated my scientific interests to the extent of me pursuing career in this area.


  • 2010, BSc Honors Molecular Biology & Genetics, Minor Neuroscience, University of Guelph
  • Currently in a chemistry PhD program at the University of Toronto.

Pre-Grad Synthetic Biology Experience

  • Awarded Bronze metal in iGEM 2008 representing the University of Guelph with goal of engineering food grade bacteria to produce beta-carotene. Proof of concept completed in E.coli.
  • Theoretical work on removal/metabolism of small molecule contaminants, particularly contraceptives such as EE2, from wastewater using engineered floc bacteria as part of WEAO competition.
  • "Weekend project". see Pharmbiants - (project suspended: may continue as part of grad work)

Research Interests

Synthetic Biology

  • Introduction and optimization of novel metabolic pathways in microorganisms for production of medically and economically important compounds.
  • Genetic manipulation/rational design of symbiotic bacteria for therapeutic purposes; elaborating host/microbe interactions, controlled drug delivery, etc.
  • Organelle-like, compartmentalization of select metabolic components for introducing modularity and increasing pathway efficiency.
  • Harnessing cellular energy for powering electronics
  • Reliable, targeted gene manipulation in eukaryotes (gene therapy).

Other Interests

  • Epigenetics: particularly of neuroplasticity.
  • Brain-machine interfaces
  • IPSC's

Favorite Synthetic Biology Related Publications

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All Medline abstracts: PubMed HubMed

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